About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Underdevelopment of Human Brain can Cause Schizophrenia

by VR Sreeraman on September 12, 2008 at 12:48 PM
Font : A-A+

 Underdevelopment of Human Brain can Cause Schizophrenia

The underdevelopment of a specific region in the human brain may be an underlying cause for schizophrenia, according to a new study published in BioMed Central's open access journal Molecular Brain.

According to the study, dentate gyrus, which is located in the hippocampus in the brain and thought to be responsible for working memory and mood regulation, remained immature in an animal model of schizophrenia.

Advertisement

Professor Tsuyoshi Miyakawa of Fujita Health University, National Institute for Physiological Sciences (NIPS), and Kyoto University led a research team in Japan, with support from the CREST program of Japan Science and Technology Agency (JST).

First, the team investigated behaviors by conducting a systematic and well-defined behavioral test battery with alpha-CaMKII mutant mice, an animal model of schizophrenia.
Advertisement

These mice showed abnormal behaviors similar to those of schizophrenic patients. Next, the team found the dentate gyrus neurons in hippocampus of the brain of these mice were not matured morphologically and physiologically.

By a gene expression analysis, changes of gene expression related to the maturation of dentate gyrus neurons were also found in the brains of schizophrenic patients. Taken together, the immaturity of the dentate gyrus may be an underlying cause for schizophrenia.

Among their findings, mice heterozygous for a null mutation of the alpha-isoform of calcium/calmodulin-dependent protein kinase II show profoundly dysregulated behaviors, including a severe working memory deficit and an exaggerated infradian rhythm (cycle of increases and decreases in locomotor activity in their home cage; 2-3 weeks/cycle), which are comparable to the symptoms observed in patients with schizophrenia, bipolar disorder and other psychiatric disorders.

Source: ANI
LIN
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
Toothache
World AIDS Day 2021 - End Inequalities, End AIDS
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Schizophrenia Parkinsons Disease Surgical Treatment Brain Brain Facts Ataxia Language Areas in The Brain Ways to Improve your Intelligence Quotient (IQ) 

Recommended Reading
Schizophrenia
Schizophrenia is a mental disorder characterized by symptoms of thought, behavior and social ......
Brain Depression - Animation
Interactive section of Medindia provides information about chemistry of Brain depression...
Ataxia
Ataxia affects coordination. Gait becomes unstable and the patient loses balance. The cerebellum or ...
Language Areas in The Brain
The mechanism of how human brain processes the language to express and comprehend the verbal, writte...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Ways to Improve your Intelligence Quotient (IQ)
Intelligence quotient (IQ) is a psychological measure of human intelligence. Regular physical and me...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use