About Careers Internship MedBlog Contact us

Type 2 Diabetes Elevates Carcinoma Risk

by VR Sreeraman on November 1, 2008 at 3:26 PM
 Type 2 Diabetes Elevates Carcinoma Risk

An Italian study has revealed that patients with type 2 diabetes mellitus (DM2) have a significantly increased risk of hepatocellular carcinoma (HCC).

Dr. Valter Donadon from Pordenone Hospital of Italy, who investigated the relationships between DM2 and risk of HCC in a large population based case-control study, also found that DM2 pre-exists to the development of HCC in most cases.


Describing the study in the World Journal of Gastroenterology, Donadon said that the research team had enrolled 465 consecutive patients with HCC compared with an age and sex matched control group of 490 subjects.

The researcher said that the new findings suggested that DM2 is more likely a concourse rather than merely a consequence of the liver tumour, a conclusion supported by the finding of a similar frequency and severity of DM2 in patients with small HCC detected during follow-up of cirrhosis and in those with more advanced and diffuse cancers detected outside of a surveillance program.

The researchers said that the observation that patients with DM2, particularly males, treated with insulin had an increased frequency of HCC was intriguing and clinically relevant.

According to them, their findings go to show that it is very important to closely observe HCC in patients with chronic liver disease and DM2, particularly when males are treated with insulin.

They further said that the in such patients strategies to improve the metabolic control should be directed primarily against hyperinsulinaemia by avoiding as much as possible the use of oral secretogogue drugs and of insulin treatment, giving preference to insulin-sensitizers such as metformin and glitazones.

Given that diabetes may be secondary to HCC or to the underlying cirrhosis, and the liver cirrhosis may be caused by diabetes, the researchers believe that further studies involving cirrhotic patients can help evaluate these complex relationships, and particularly whether the diabetes itself has a direct carcinogenetic effect.

Source: ANI
Font : A-A+



Recommended Readings

Latest Cancer News

Personalized Vaccine and T Cell Therapy for Ovarian Cancer Patients
The combination of the personalized cancer vaccine with ACT led to ovarian cancer control in few patients within a span of three months, stated study results.
Kinase-Targeted Therapy Revolutionizes Colorectal Cancer Care
Uncovering key kinases in tumor growth and invasion is crucial for improving targeted therapies in advanced-stage colorectal cancer.
Novel Photo-Oxidation Therapy Holds Promise for Anticancer Treatment
The study findings validate metal-enhanced photo-oxidation for future metal-based anticancer drugs.
Mutations in 11 Genes Linked to Aggressive Prostate Cancer
Mutations in 11 genes are linked to aggressive forms of prostate cancer, which may present novel therapeutic and therapy options.
Link Between Poor Oral Health and Head & Neck Cancer Survival Uncovered
Improved oral health, as indicated by the count of natural teeth and dental appointments preceding the diagnosis, correlated with enhanced head and neck cancer survival rates.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
Greetings! How can I assist you?MediBot

Type 2 Diabetes Elevates Carcinoma Risk Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests