Two types of blood thinning drugs were found to be safe and can be used in patients with an irregular heartbeat while undergoing surgery.
The anticoagulant drugs, Apixaban and Vitamin K antagonists (VKAs) also may have a positive impact on a patient's cognitive function.
The trial was led by the University of Birmingham and the research was published in European Heart Journal.
Specialist teams can cure atrial fibrillation by stopping the irregular electrical signals in the heart that cause the symptoms via a procedure known as catheter ablation.
In this procedure, an electrophysiologist uses a long wire, threaded into the heart via the groin, to deliver a high-frequency electric current. This heats the inner surface of the heart where the irregular electrical signals occur, creating scar tissue and so preventing the faulty impulses.
Patients with atrial fibrillation are at their greatest risk of stroke in the hours and days following this procedure. Therefore, they require anticoagulants to thin the blood and prevent blood clots.
To determine the optimal anticoagulation therapy for patients undergoing catheter ablation, the German Atrial Fibrillation NETwork (AFNET), in cooperation with the German Centre for Cardiovascular Research, (DZHK) carried out the AXAFA - AFNET 5 trial comparing Apixban and VKAs.
In the randomised trial, 633 patients in Europe and the USA received either continuous Apixaban or a VKA before and post their catheter ablation.
Professor Paulus Kirchhof, of the University of Birmingham's Institute of Cardiovascular Sciences, International Chief Investigator of the clinical trial and Chairman of AFNET, said: "Catheter ablation is being used increasingly to treat patients with symptomatic atrial fibrillation, but the procedure leaves patients at a certain risk of stroke, bleeding, and clinically silent acute brain lesions. We also know that thrombotic events can impair cognitive function.
"We found the bleeding rate was half of what we have expected and there was a remarkably low rate of stroke, with only two events being observed in the trial.
"In addition, seven episodes of cardiac tamponade - two with Apixaban and five with a VKA - were managed with drainage, without the need for antidotes."
Using the Montreal Cognitive Assessment test, the investigators found a small but statistically significant improvement in cognitive function in both study groups at the end of the study.
Another unique feature of the trial was the use of brain magnetic resonance imaging (MRI) in more than half of the study patients within 48 hours after ablation to quantify procedure-related acute ischaemic brain lesions.
The results of the brain MRI substudy demonstrated no difference in clinically silent acute brain lesions between the treatment arms.
Professor Kirchhof said that the results of the trial will have a big impact on treatment: "The results of this trial will go a long way towards reassuring clinicians that continuous Apixaban is a safe and effective alternative to VKA for patients undergoing atrial fibrillation ablation, even those at risk of stroke."
Professor Kirchhof is presenting an abstract of these findings today (March 20) at the European Society of Cardiology's Congress in Barcelona, Spain.