About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Turn-off Switch for Inflammation Discovered

by Anjali Aryamvally on March 30, 2018 at 9:20 AM
Font : A-A+

Turn-off Switch for Inflammation Discovered

A new metabolic process in the body has been discovered that can switch off inflammation linked to several diseases including arthritis, inflammatory bowel disease and heart disease.

The study, published in the journal Nature, showed that "itaconate" -- a molecule derived from glucose -- acts as a powerful off-switch for macrophages, which are the cells in the immune system that lie at the heart of many inflammatory diseases.

Advertisement


"It is well known that macrophages cause inflammation, but we have just found that they can be coaxed to make a biochemical called itaconate," said one of the lead researchers Luke O'Neill, Professor at Trinity College Dublin in Ireland.

"This functions as an important brake, or off-switch, on the macrophage, cooling the heat of inflammation in a process never before described," O'Neill said.
Advertisement

The researchers believe that the findings could help develop much-needed new drugs to treat people living with inflammatory and infectious diseases.

"The macrophage takes the nutrient glucose, whose day job it is to provide energy, and surprisingly turns it into itaconate. This then blocks production of inflammatory factors, and also protects mice from the lethal inflammation that can occur during infection," said study first author Evanna Mills from Trinity College Dublin.

The discoveries were made using both human cells and mice as a model organism.



Source: IANS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
Fermented Skin Care
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Anti-Inflammatory Diet Inflammation Top Ten Foods That Trigger Inflammation 

Recommended Reading
Top Ten Foods That Trigger Inflammation
Foods like refined carbohydrates, sugar, certain types of fat, artificial food additives and ......
Conjunctivitis
Conjunctivitis or Pink Eye causes redness and soreness of the conjunctiva and is responsible for 1% ...
Uveitis
Uveitis refers to inflammation of the uvea of the eye resulting in swelling and destruction of eye ....
Gout
High levels of uric acid in blood and recurring attacks of joint inflammation are the main symptoms ...
Anti-Inflammatory Diet
Healthy foods as part of anti-inflammatory diet to fight inflammation are basic components of the Me...
Inflammation
Inflammation is the response of living tissue to injury due to a variety of causes that call upon ho...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)