UCLA researchers, for the first time have shown that modulating the hormonal environment in which endometrial cancers grow could make tumors significantly more sensitive to a new class of drugs known as PARP inhibitors.
The findings could lead to a novel one-two punch therapy to fight endometrial cancers and provide an alternative option for conventional treatments that, particularly in advanced disease, have limited efficacy.
Endometrial Cancer
Cancer of the Endometrium, or the inner lining of the uterus (womb) is called endometrial cancer.
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Studies on endometrial cancer cell lines have shown that PARP inhibition induces cell death when tumor suppressor PTEN is missing, a defect found in about 80 percent of human endometrial cancers. However, the UCLA researchers wanted to test the inhibitors in a laboratory model with a tumor microenvironment that closely resembles human endometrial cancer to see if this therapy would be effective, said study senior author Dr. Sanaz Memarzadeh, an assistant professor of obstetrics and gynecology and director of the G.O. Discovery Lab at UCLA.
The study appears XXX in Molecular Cancer Therapeutics, a peer-reviewed journal of the American Association for Cancer Research.
"A PARP inhibitor was given orally in two hormonal extremes - high and low estrogen," Memarzadeh said. "The treatment achieved a significant reduction in tumor size in a low estrogenic milieu. In striking contrast, no response to the inhibitor was seen in tumors exposed to high levels of estrogen."
Source: Eurekalert
"A PARP inhibitor was given orally in two hormonal extremes - high and low estrogen," Memarzadeh said. "The treatment achieved a significant reduction in tumor size in a low estrogenic milieu. In striking contrast, no response to the inhibitor was seen in tumors exposed to high levels of estrogen."
Source: Eurekalert
Uterine Cancer
Uterine Cancer or Cancer of the Uterus (or Endometrial Cancer) refer to cancers affecting the uterus or the womb in women. Learn about the different types of uterine cancer, symptoms, staging, diagnosis, prognosis, treatment, survival rates and news on uterine cancer.
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 Women and CancerCancer is one of the frequently talked about and most feared disease that falls under the genre of lifestyle diseases that have evolved, rather rapidly, in the past two decades. | Advertisement
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Endometrial Cancer Promoted By Epigenetic Silencing of the HAND2 Tumor Suppressor: Study
Epigenetic modification of the HAND2 gene plays a critical role in the development of endometrial cancer, suggests a new study published this week in PLOS Medicine .
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