Combined tumor-killing therapy was developed by Chinese scientists that can be activated explicitly at tumor sites in mouse models of cancer. This type of treatment is more effective than previous similar therapies.
The study published on Friday in the journal Science Immunology described the new cancer immunotherapy that can prevent the immune system from becoming tolerant of tumors, which occurs in 30 per cent of all cancer patients, the Xinhua news agency reported.
Cancer Immunotherapy
Cancer immunotherapy is a new advancement in cancer treatment that uses certain components of a person''s immune system to fight against cancer cells.
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‘A combination of nanoparticles and PD-L1- targeting antibodies with a light-activated molecule called a photosensitizer, can kill the tumor cells by producing tumor-killing reactive oxygen species.’
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A team led by Wang Dangge from Shanghai Institute of Materia Medica under the Chinese Academy of Sciences and Fudan University developed a common immune checkpoint inhibitor in a nanoparticle formulation, which is highly tumor-specific.
The checkpoint inhibitor is a kind of increasingly popular anti-tumor drug. It can block proteins that keep immune T cells from killing cancer. But the checkpoint inhibitor used to target those immune system-suppressing proteins like PD-1 and PD-L1 often fails to reach deep-seated or metastatic tumors.
![CAR T-Cell Therapy]( "CAR T-Cell Therapy")
CAR T-cell therapy is a type of gene therapy where the patient's T-lymphocytes are genetically altered to target cancer cells within the patient's body.
Wang's team combined the nanoparticles carrying PD-L1-targeting antibodies with a light-activated molecule. The molecule called photosensitizer can produce tumor-killing reactive oxygen species after encountering a protein abundant in tumors, according to the study.
In mouse models, a local near-infrared radiation that activated the photosensitizer, along with the administration of antibodies-carrying nanoparticles, promoted the infiltration of cancer cell-killing T cells into the tumor site and made the tumors more sensitive to the checkpoint blockade.
This combination also helped the nanoparticles effectively suppress tumor growth and metastasis to the lung and lymph nodes, resulting in approximately 80 per cent mouse survival over 70 days, compared to complete mouse death in 45 days in the group treated with only PD-L1 antibodies, according to the study.
Source: IANS
CAR T-Cell Therapy
CAR T-cell therapy is a type of gene therapy where the patient's T-lymphocytes are genetically altered to target cancer cells within the patient's body.
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Wang's team combined the nanoparticles carrying PD-L1-targeting antibodies with a light-activated molecule. The molecule called photosensitizer can produce tumor-killing reactive oxygen species after encountering a protein abundant in tumors, according to the study.
In mouse models, a local near-infrared radiation that activated the photosensitizer, along with the administration of antibodies-carrying nanoparticles, promoted the infiltration of cancer cell-killing T cells into the tumor site and made the tumors more sensitive to the checkpoint blockade.
This combination also helped the nanoparticles effectively suppress tumor growth and metastasis to the lung and lymph nodes, resulting in approximately 80 per cent mouse survival over 70 days, compared to complete mouse death in 45 days in the group treated with only PD-L1 antibodies, according to the study.
Source: IANS
Screening for Breast Cancer with Clinical Breast Examination
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