About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Blood Vessel Formation can be Targeted to Inhibit Tumor Growth

by Rishika Gupta on December 22, 2017 at 12:45 PM
Font : A-A+

New Blood Vessel Formation can be Targeted to Inhibit Tumor Growth

Angiogenesis promoting proteins can be targeted to hinder tumor growth. To grow and multiply, tumors can source nutrients from the new blood vessels. The findings of this study is further discussed in PLOS Computational Biology journal.

"Identifying a measurement or quantity that predicts how specific tumors will respond, called a predictive biomarker, is extremely valuable to cancer research," said Stacey Finley, a USC assistant professor of Biomedical Engineering and co-author to the study. Finley, a Gordon S. Marshall Early Career Chair, is also a faculty member of the new USC Michelson Center for Convergent Bioscience.

Advertisement


Tumors exploit a biological process called angiogenesis, which is the formation of new blood vessels from pre-existing ones. To grow and multiply, tumors source nutrients delivered by this new vasculature. But tumor growth will slow down if proteins like vascular endothelial growth factor (VEGF), an angiogenesis promoter, are waylaid.

The research team used a computational model of tumor-bearing mice (verified by published experimental data) to investigate the response to VEGF-inhibiting drugs and how this response is affected by tumor development. The model illuminated that certain properties of tumor growth help forecast whether drug therapy will thwart tumor expansion.
Advertisement

"We found that certain parameters about the way the tumor grows could successfully and accurately predict the response to anti-angiogenic treatment that inhibits VEGF signaling in the mouse," Finley said. "Using the characteristics of the tumor's growth, we can predict how effective the anti-angiogenic therapy will be, or whether the tumor's growth will slow down, even before treatment begins."

A next step in the research includes a mathematical model to simulate a virtual population of mice randomly assigned different tumor growth parameters. The model will mimic tumor growth with and without drug therapy- and be able to predict mice who respond to drug therapy (resulting in slower tumor growth) and mice with no effect. The research team will further use experimental data to validate the model's predictions.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Thalassemia Vasculitis Tumor Markers For Cancer Diagnosis and Prognosis Blood in Stools - Symptom Evaluation Bombay Blood Group Angiogenesis 

Recommended Reading
Hope for New TB Treatment With Drugs to Block Angiogenesis
Tobin helped to develop the zebrafish as a model of Tuberculosis, and is now ready to use the ......
Angiogenesis Factor May Promote Aging-Related Eye Conditions
Increased expression of the angiogenic factor VEGF-A promotes three common aging-related eye ......
Plerixafor Blocks Pathway That Limits Anti-Angiogenesis Therapy
New FDA approved drug, plerixafor, which is a CRCX4 inhibitor, reduces resistance to ......
How Anti-Angiogenesis Treatment Would Help Eliminate a Tumor
Deciphering and targeting mechanisms involved in resistance to anti-angiogenic therapy is critical ....
Angiogenesis
Angiogenesis is the process of formation of new blood vessels from pre-existing blood vessels. It oc...
Blood in Stools - Symptom Evaluation
Blood in stools results from bleeding that arises from any part of the digestive tract. Causes of bl...
Bombay Blood Group
Bombay blood group is a rare blood type in which the people have an H antigen deficiency. They can r...
Thalassemia
Thalassemia is an inherited blood disorder passed on through parental genes causing the body to prod...
Tumor Markers For Cancer Diagnosis and Prognosis
An ideal tumor marker for a cancer should be specific to that cancer and not generate false positive...
Vasculitis
Vasculitis is an inflammation of the blood vessels of the body that can affect people of all ages; i...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use