In "Acute Chest Syndrome in Children with Sickle Cell Disease," coauthors Shilpa Jain, Women and Children's Hospital of Buffalo and Hemophilia Center of Western New York, Buffalo, and Nitya Bakshi and Lakshmanan Krishnamurti, Children's Healthcare of Atlanta, GA, examine the multiple factors that can contribute to a child's increased risk of ACS and proposed mechanisms by which ACS may develop. The researchers also provide a comprehensive review of the clinical features of ACS in this patient population, preventive approaches including the use of hydroxyurea, and what is needed to achieve a prompt diagnosis.
‘Preventive approaches including the use of hydroxurea, effective therapies and pain control are discussed.’
"Management of acute chest syndrome is a major challenge for physicians and other healthcare providers caring for children with sickle cell disease. Not only can episodes recur but damage from repeated episodes can lead to pulmonary infarcts, fibrosis and deterioration in lung function." says Pediatric Allergy, Immunology, and Pulmonology Editor-in-Chief Mary Cataletto, MD, Professor of Clinical Pediatrics, Stony Brook University School of Medicine. "It is not only important to know how to recognize and treat an acute episode but to be able to implement long term management strategies to try and prevent future episodes."