"Breast cancer patients who received anthracycline and taxane-based chemotherapy with or without trastuzumab maintained excellent cardiac function a median of 8.8 years after treatment was started. In addition, patient reports of greater cardiac symptoms indicated more cardiac problems in the small group who had difficulties. Overall, for the relatively young women who entered this trial, the risks of cardiac late effects were minimal," commented Patricia A. Ganz, MD, of the University of California, Los Angeles, lead author of the article. Co-author Edward Romond of the University of Kentucky, Lexington, added, "
. We owe a great debt of thanks to the women who participated in this clinical trial."
‘Breast cancer patients who received chemotherapy with or without trastuzumab maintained excellent cardiac function a median of 8.8 years after treatment initiation.’
Prior to this study, limited information was available regarding the long-term follow-up of cardiac function and health-related quality of life in patients who remained disease-free following the completion of adjuvant chemotherapy. Previous studies suggested that early cardiac toxicity was a risk associated with adjuvant treatment when combined with trastuzumab. However, at median follow-up of almost 9 years, patients who were treated with anthracycline and taxane-based chemotherapy with added trastuzumab on NRG Oncology/NSABP B-31 did not experience long-term worsening of cardiac functioning or health-related quality of life
Researchers assessed cardiac function through the measurement of left ventricular ejection fraction by multiple-gated acquisition (MUGA) scan and health-related quality of life using the Duke Activity Status Index (DASI) and the Medical Outcomes Study questionnaire. Current medications and comorbid conditions were also considered. Only 4.5% of patients from the control group and 3.4% from the trastuzumab group had a >10% decline in left ventricular ejection fraction from the baseline to a value <50%. Lower DASI scores were linked with age and use of certain medications yet lower scores did not correlate with the addition of trastuzumab. Moving forward, the DASI could prove beneficial for monitoring patient-reported changes with regard to cardiac functioning.