About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Transplanted Neurons may Help in Repairing the Stroke-Injured Brain

by Dr. Trupti Shirole on January 24, 2017 at 11:28 AM
Font : A-A+

 Transplanted Neurons may Help in Repairing the Stroke-Injured Brain

Currently, there is no effective treatment which can restore function in a stroke patient once the first hours following a stroke have passed. But, in the future, the stroke-injured brain could be reparable by replacing dead cells with new, healthy neurons, using transplantation.

Researchers at Lund University in Sweden have taken a step in that direction by showing that some neurons transplanted into the brains of stroke-injured rats were incorporated and responded correctly when the rat's muzzle and paws were touched.

Advertisement


The study, published in the prestigious journal Brain, used human skin cells. These cells were re-programmed to the stem cell stage and then matured into the type of neurons normally found in the cerebral cortex.

A couple of years ago, the research team at the Stem Cell Center in Lund had already proven that transplanting this type of cells to the cerebral cortex enabled stroke-injured rats to move better. At the time, however, it was unclear whether the host brain really formed functioning connections with the transplanted nerve cells. Now the new study has proven that this is indeed the case.
Advertisement

The research team used several advanced methods in the study - electron microscopy, virus-based tracing techniques, registration of activity in the transplanted cells and optogenetics. The results show that various parts of the host brain form normal, functioning connections with the transplanted neurons and that the latter change their activity when the animal's muzzle and paws are touched.

"This is the first time anyone has been able to show such a result. That some of the new nerve cells receive signals from the host brain in a normal way indicates that they have been incorporated into the stroke-injured rat's brain. In it, they have been able to replace some of the dead nerve cells", says the professor at the Stem Cell Center, Zaal Kokaia.

Now, a stroke-injured laboratory animal is not the same as a stroke patient. But professor and consultant physician Olle Lindvall, who is also part of the research team, still sees the team's study as an important first step. It constitutes what is known as proof of concept, showing that it is possible to replace dead neurons with new, healthy cells through transplantation after a stroke.

"This is basic research, and it is not possible to say when we will be ready to start experiments on patients. But the objective is clear: to develop a treatment method which can repair the stroke-injured brain.", says Zaal Kokaia.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
Test Your Knowledge on Sugar Intake and Oral Health
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Parkinsons Disease Surgical Treatment 

Most Popular on Medindia

Daily Calorie Requirements Drug - Food Interactions Find a Hospital Indian Medical Journals Blood - Sugar Chart Hearing Loss Calculator Drug Interaction Checker Find a Doctor How to Reduce School Bag Weight - Simple Tips A-Z Drug Brands in India
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Transplanted Neurons may Help in Repairing the Stroke-Injured Brain Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests