Perimenopause, the transition women go through prior to menopause, causes abnormal periods, erratic fluctuations in hormone levels, insomnia and, for many women, unpleasant hot flashes. Did you know you're two-to-four-times more likely to suffer from depression during the menopause transition?
A new study suggests that transdermal estradiol could be the key to not only treating existing perimenopausal depression, but also possibly preventing it, and the chances that it will benefit your mood are greater the more stress you're under. The study results will be presented during The North American Menopause Society (NAMS) Annual Meeting in Philadelphia, October 11-14, 2017.
It's no secret that depression is a commonly reported symptom of the menopause transition. Several small trials have previously suggested that transdermal estradiol therapy (i.e., an estrogen patch) effectively treats perimenopausal depression. But this is the first study to examine its effectiveness in preventing the onset of perimenopausal depression among women who were previously not depressed. Estradiol is the primary estrogen (female sex hormone) that is produced during a woman's reproductive years, impacting reproduction as well as sexual function.
"This study suggests that the stabilization of fluctuating estradiol levels, which are characteristic of the menopause transition, with transdermal estradiol may represent one option for preventing the development of depressive symptoms in the menopause transition," says Dr. Jennifer Gordon, a lead researcher on the study team from the University of Regina in Saskatchewan, Canada.
"An interesting finding in this study is the impact of recent life events, which signals that healthcare providers may need to inquire about such events when determining whether or not to prescribe transdermal estradiol to influence mood in perimenopausal women experiencing depressive symptoms," says Dr. JoAnn Pinkerton, NAMS executive director."
Drs. Gordon and Pinkerton are available for interviews before the presentation at the Annual Meeting.