A study by Jonathan Graff and colleagues, reported in EMBO, has revealed that the enzyme TPPII may contribute to obesity by stimulating the formation of fat cells. It has previously been linked to making people feel hungry but now it has been shown that it may be even more deeply involved in causing obesity.
The team found that TPPII actually stimulated the formation of fat cells in worms and mammalian cells and that by reducing it, fat stores decreased. Mice with lower levels of TPPII were thinner than their wild type littermates, although their food intake was comparable.
The authors hope that TPPII could be exploited as a drug target to help fight increasing levels of obesity; inhibiting the enzyme would both increase feelings of fullness after eating and decrease build up of fat cells.