Excess Iron could hasten the development of Alzheimer's disease, according to a new research.
The study by researchers in Australia also reveals the role of beta-amyloid precursor protein (APP), which forms plaques in affected brains.
Alzheimers Disease
Alzheimer''s disease is a progressive neurodegenerative disease affecting memory and thinking and making the person increasingly dependent on others.
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To each the conclusion, Jack Rogers at the University of Melbourne and colleagues, used mouse studies, healthy human brain cells and post-mortems to show that APP's role is probably to flush toxic iron from neurons.
However, in Alzheimer's, the APP's function is sabotaged by zinc, which accumulates in the disease's trademark plaques, reports New Scientist.
Normally, zinc aids neuronal signalling, but as it becomes trapped in plaques, it both disrupts APP's iron-clearing role and denies neurons the zinc they need for signalling.
The outcome is a double-whammy, which sees iron continuing to accumulate and neurons losing their ability to signal appropriately.
Source: ANI
Normally, zinc aids neuronal signalling, but as it becomes trapped in plaques, it both disrupts APP's iron-clearing role and denies neurons the zinc they need for signalling.
The outcome is a double-whammy, which sees iron continuing to accumulate and neurons losing their ability to signal appropriately.
Source: ANI
Diseases Related to Old Age
Ageing is referred to the accumulation of changes that brings a person closer to death.
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 Iron & Folate Deficiency Anemia In PregnancyAbout 95% of the anemia cases are due to iron deficiency. | Advertisement
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