A new study suggests that environmental factors of present day could influence the health of generations to come.

The findings suggest nicotine can leave heritable epigenetic marks on the genome, which make future offspring more susceptible to respiratory conditions.
The researchers also cited the Children's Health Study from Southern California, which reported that grandmaternal smoking during pregnancy increases the risk of asthma in grandchildren regardless of whether the mother smoked or not.
Based on those findings, the researchers conclude that environmental factors experienced during pregnancy will affect not only the child in utero but also future generations of the same family. They say this multi-generational transmission could explain why 98% of inherited human diseases are unaccounted for by the prevailing view of genetic trait transmission, known as Mendelian genetics.
The researchers concluded that the cause of the second generation's asthma was epigenetic modification (an environmental factor causing a genetic change). Nicotine was affecting both the lung cells and the sex cells in ways that caused the lungs that developed from those cells to develop abnormally, causing asthma.
"These studies break new ground in validating and further explaining the mechanisms involved in the transmission of epigenetic human diseases," Dr. Torday said. "The transmission of the asthma to the second generation and its prevention by a specifically-targeted molecular intervention are the first unequivocal demonstrations of multi-generational transmission of an epigenetically-mediated effect on the offspring."
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"Asthma is the most common chronic disease of childhood, resulting in a significant impact on the lives of children and driving up medical costs for all," Dr. Rehan said. "While many factors contribute to asthma, smoking during pregnancy is a well-established one and one that can be avoided. Eliminating smoking during pregnancy would significantly reduce the prevalence of childhood asthma for this generation and for future generations."
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Source-Eurekalert