The model shows that clinical signs of coronavirus disease appear within 24 hours of infection. These signs include reduced appetite, elevated temperature, increased respiratory rate, cough, goose bumps and hunched posture. In monkeys and humans, the infection causes disease deep in the lungs, leading to pneumonia. Scientists are exploring whether the virus' foothold in the lower respiratory tract impedes its ability to spread efficiently.
Researchers at NIH's National Institute of Allergy and Infectious Diseases (NIAID) developed the model after obtaining coronavirus samples from collaborators at Erasmus Medical Center in The Netherlands.