Sorting out the differences between a mouse model and the human model of kidneys, scientists can build tiny kidneys for drug testing.
Solitary Kidney - Causes, Symptoms, Diagnosis, Treatment
Solitary kidney does not pose a grave health risk but it does require additional care. Find out how solitary kidney affects one’s health and quality of life and how to live with the condition.
Solitary kidney does not pose a grave health risk but it does require additional care. Find out how solitary kidney affects one’s health and quality of life and how to live with the condition.
‘'Progenitor cells' (green), which are similar to stem cells can be used to build tiny kidneys. These kidneys can be used for testing drugs to help treat kidney diseases.’
Over the past four years, USC Stem Cell researchers and USC Viterbi School of Engineering computer scientists have documented the molecular, cellular and genetic similarities and differences between human and mouse kidney formation so they can find treatments for kidney disease, which affects about 30 million Americans or 15 percent of U.S. adults. The three-study series, published on Feb. 15 in the Journal of the American Society of Nephrology, provides the first cellular and molecular characterization of how the human kidney develops in a mother's womb, said Andrew McMahon, study senior author and W.M. Keck Provost Professor of Stem Cell Biology and Regenerative Medicine and Biological Sciences at the Keck School of Medicine.
Kidney research has been a focus of the McMahon Lab for the past quarter-century. "Our research bridges a critical gap between animal models and human applications," McMahon said. "The data we collected and analyzed creates a knowledge-base that will accelerate stem cell-based technologies to produce mini-kidneys that accurately represent human kidneys for biomedical screening and replacement therapies."
About Transplantation
Since the early times, the novel idea of transplanting tissues and other body parts from one organism to the other has captured the imagination of successive generations.
Since the early times, the novel idea of transplanting tissues and other body parts from one organism to the other has captured the imagination of successive generations.
The kidney plays a central role in controlling the body's ecosystem by regulating blood pressure and removing waste products.
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Diabetic nephropathy refers to kidney damage due very high levels of blood sugar levels in diabetics.
Diabetic nephropathy refers to kidney damage due very high levels of blood sugar levels in diabetics.
USC Stem Cell researchers analyzed the developmental differences in scale, timing and basic structure between human and mouse kidneys. They gained insight into the regulatory processes that maintain, expand and turn kidney stem cells into mature, functional kidney structures by examining human kidneys at different stages of development and juxtaposing their observations with mouse kidneys.
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Paired Donor Exchange Kidney Transplantation
Paired donor exchange kidney transplantation is a process in which unrelated kidney donors are matched to recipients so that compatible transplants can be performed.
Paired donor exchange kidney transplantation is a process in which unrelated kidney donors are matched to recipients so that compatible transplants can be performed.
Intractable problems require multidisciplinary collaboration
The median wait time for a kidney transplant is 3.6 years, meaning people have to put their lives on standby for years as they go to three dialysis appointments per week.
Kidney disease is a big, intractable problem, so it requires a multidisciplinary approach. That's why McMahon teamed up with Carl Kesselman, study co-author and Dean's Professor of Industrial and Systems Engineering at USC Viterbi.
Kesselman and his team at the Information Sciences Institute at USC Viterbi built software that automated many of the tasks researchers needed to perform, such as recording data observed by a high-resolution microscope. The tool not only fast-tracked one of the three studies but also created an online, searchable library to help other stem cell scientists in their kidney disease research.
"If you think of data as the modern version of a book, we gave the researcher tools to write the book, made the library where the book is stored and created a catalog system so others can find the book and check it out," said Kesselman, a principal investigator at the USC Michelson Center for Convergent Bioscience.
To achieve this, Kesselman's team created DERIVA (Discovery Environment for Relational Information and Versioned Assets), a software program that collected data from microscopes and organized them and other study data into virtual photo albums that easily can be shared with other researchers.
"It's the difference between taking a photo with film or taking it with your smartphone and using the metadata that is automatically generated to organize your photos," Kesselman said.
"At some point, you have so many photos that they become unmanageable. You can't find the one you want. DERIVA automatically catalogs your data so you can analyze massive amounts of data with Zen-like calm and share them with all of your friends throughout the world."
Source-Eurekalert
