About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Therapeutic Inhibition of RANK Pathway Reduces Recurrence of Breast Cancer

by Dr. Trupti Shirole on September 14, 2016 at 10:04 PM
Font : A-A+

 Therapeutic Inhibition of RANK Pathway Reduces Recurrence of Breast Cancer

Cancer stem cells (CSC) express high levels of RANK protein. Inhibitors of the RANK signaling pathway are already approved for clinical use. RANK inhibitors are currently used in patients with osteoporosis and in the prevention of skeletal-related events in patients suffering from bone metastases due to tumors.

Pharmacological and genetic inhibition of signaling pathway RANK / RANKL leads to a significant reduction in recurrences and metastases in breast cancer in a mouse animal model, revealed researchers at the Institute of Biomedical Research of Bellvitge (IDIBELL), led by Dr. Eva Gonzalez-Suarez.

Advertisement


The findings, published in Cancer Research, suggest that RANK inhibitors may have potential for treating breast cancer.

"In fact, mortality in breast cancer is mainly due to survivor CSC after treatments, which are responsible for tumor recurrence and metastasis" explains Dr. Gonzelez-Suerez. "Previous studies of this and other research groups have shown that inhibition of RANK pathway may prevent breast cancer, but no one had proven the potential of RANK pathway inhibitors in the treatment of disease."
Advertisement

In their latest work, researchers show that inhibition of the RANK / RANKL signaling pathway could potentially be used as a new therapy in breast cancer; as Dr. Gonzelez-Suerez puts it, "this inhibition does not reduce tumor growth, but promotes differentiation, reducing the population of CSC and impairing metastasis, which improves the prognosis."

Under normal conditions, the RANK / RANKL bone metabolism protein pair act as a translator of the information provided by sex hormones such as progesterone and sends a signal which stimulates the development of the mammary gland. This occurs in all women during pregnancy and during the menstrual cycle; however, if the signaling pathway is disregulated, mammary cells begin to divide and multiply and die when they should not, leading to breast cancer.

"As these preclinical experiments suggest, and given that the RANKL / RANK pathway plays an important role in the development of primary breast cancer, inhibitors could serve as a potential target for the prevention and nonsurgical treatment of breast cancer," the researcher concludes.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge About Chromosomes?
Eating During Sunlight Hours Minimizes Mood Vulnerabilities
Know More About the Digestive System
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Breast Biopsy Pagets disease of the breast Mastitis Cancer and Homeopathy Breast Cancer Facts Cancer Facts Cancer Tattoos A Body Art Breasts - Structures and Types 

Most Popular on Medindia

Color Blindness Calculator Pregnancy Confirmation Calculator Find a Hospital Diaphragmatic Hernia A-Z Drug Brands in India Drug Interaction Checker Blood Pressure Calculator Drug - Food Interactions Sinopril (2mg) (Lacidipine) Loram (2 mg) (Lorazepam)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Therapeutic Inhibition of RANK Pathway Reduces Recurrence of Breast Cancer Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests