A group of experts has provided a set of recommendations to help guide future research on Alzheimer's disease, and may help determine why the disease affects twice as many women as men.
An estimated 5.4 million Americans are affected by AD and related dementias, and that number will likely rise to 11-16 million people by the year 2050 if no effective cures or preventive measures are developed.
The main risk factors for AD are age and sex, with affected women outnumbering men 2 to 1. This may be due at least in part to the fact that women tend to live longer.
The consensus recommendations encompass seven themes, including the need to assess the link between sex and AD incidence, raise awareness of sex differences among the research community, and to take into account sex-based differences in the experimental design and data analysis of studies on disease risk, early diagnosis, and drug discovery.
The recommendations are published in a Roundtable discussion in Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers.
"There are still major gaps in our knowledge of the role of sex and gender in the onset and progression of Alzheimer's disease, and these recommendations will provide a useful guide for future research in this area," said Susan G. Kornstein, MD, Editor-in-Chief of Journal of Women's Health, Executive Director of the Virginia Commonwealth University Institute for Women's Health, Richmond, VA, and President of the Academy of Women's Health.