About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

The Innovative Dual Action Anthrax Vaccine Discovered

by Medindia Content Team on October 6, 2007 at 6:00 PM
Font : A-A+

The Innovative Dual Action Anthrax Vaccine Discovered

Tests on rats showed that their immune system against lethal toxins became stronger and improved faster with only one injection of the vaccine.

Concerns about anthrax-a potentially fatal disease caused by the spore-forming, gram-positive bacterium Bacillus anthracis-as a weapon of bioterrorism has prompted increased efforts to develop better antitoxins and vaccines.

Advertisement

The vaccine in use presently, which was developed in the 1950s, is safe and effective, but requires multiple injections followed by annual boosters.

Current anthrax treatment involves antibiotics such as ciprofloxacin and doxycycline that attack the bacteria but provide no protection against the dangerous toxins secreted by the bacteria.
Advertisement

The new study, on the other hand, introduces a highly effective dual-action compound that leapfrogs current efforts to develop a second-generation anthrax vaccine.

In the research, the scientists created a "multivalent display," with several sites of attachment for recombinant protective antigen protein (PA), the primary component of the current anthrax vaccine, rather than only one.

Virus-like particles coated with PA were found to produce a potent toxin-neutralizing antibody response that protected rats from the lethal anthrax toxin after only a single immunization.

Scripps Research scientist Anette Schneemann, who developed the vaccine along with Marianne Manchester, and Salk Institute Prof. John A.T. Young, said the antitoxin strategy arose from the discovery of the anthrax toxin receptor, ANTXR2, in Prof. Young's lab

"The new anti-anthrax agent is based on a multivalent display of ANTXR2 on the surface of an insect virus. Our approach was based on the assumption that a multivalent display of recombinant protective antigen protein would induce a far more potent immune response. That turned out to be correct," said Schneemann.

She said the new vaccine-antitoxin combination was based on the multivalent display (180 copies) of the PA-binding von Willebrand A (VWA) domain of the ANTXR2 cellular receptor on the Flock House virus.

The chimeric virus-like particle platform, which produces protective immunity and has been shown to be safe, inhibited lethal toxin action in vitro and in vivo models of anthrax infection, she said.

She said rats survived exposure to the toxin four weeks after a single injection of the new double-acting agent.

"This result suggests an extremely rapid production of neutralizing antibodies without the use of an adjuvant, a secondary agent that helps stimulate the immune system and is often used to increase the vaccine response-key goals for the development of third-generation anthrax vaccines," she said.

"The new anti-anthrax agent that we developed is an important and potentially critical development for anyone who works with the bacterium or those who might be exposed to it in a bioterrorism attack. While other strategies are being pursued to develop improved anthrax vaccines, none of these offer the distinct advantage of combining the function of a vaccine with a potent antitoxin," Schneemann added.

The study appears in the October 5 issue of the journal PLoS Pathogens

Source: ANI
SPH /J
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
How to Battle Boredom during COVID
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Anthrax Bioterrorism Top 10 Vaccine Myths Debunked 
Recommended Reading
Anthrax
Anthrax is caused by the bacterium Bacillus anthracis and spreads when the anthrax spores are inhale...
Top 10 Vaccine Myths Debunked
Childhood vaccination has saved many lives, yet lots more has to be done to increase awareness and e...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use