The Fundamental Basis of Precision Medicine

by Bidita Debnath on  June 7, 2017 at 11:21 PM Research News
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If a drug do not suit your body type, it can lead to adverse effects on the body. A lot of drugs, over the last decade, have been pulled out from the market due to toxicity, as they affected women more than men.
 The Fundamental Basis of Precision Medicine
The Fundamental Basis of Precision Medicine

The studies that brought the drugs to market were designed using only male cells and animal models, a common flaw a Tulane endocrinologist is working to help correct. "We really need to study both sexes," says Dr. Franck Mauvais-Jarvis, a leading voice in the debate to bring sex parity to pre-clinical research. "The focus on a single sex threatens to limit the impact of research findings as results may be relevant to only half of the population."

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Mauvais-Jarvis, a professor of endocrinology at Tulane University School of Medicine, is the lead author of a newly published article in the journal Cell Metabolism to help scientists who study obesity, diabetes or other metabolic diseases better account for inherent sex differences in research.

While the National Institutes of Health recently mandated researchers consider sex as a biological variable by including both sexes in pre-clinical research, there is little guidance in designing studies to fully consider sex differences in underlying biological mechanisms. The article outlines the causes of sex differences in research models and the methods for investigators to account for these factors.

Mauvais-Jarvis' goal is to help investigators better understand that sex differences are not simply a superficial aspect of research that only account for different sets of hormones. He maintains that male and female are two different biological systems.

"Sex differences are at the core of the mechanism for biological traits and disease," Mauvais-Jarvis says. "We believe that the incorporation of appropriately designed studies on sex differences in metabolism and other fields will accelerate discovery and enhance our ability to treat disease. This is the fundamental basis of precision medicine"

Source: Eurekalert

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