About My Health Careers Internship MedBlogs Contact us

The Eye is Not Immune Privileged

by Bidita Debnath on January 28, 2018 at 11:53 PM
Font : A-A+

The Eye is Not Immune Privileged

The interior of the eye lacks lymph vessels but is highly vascularized. A person needs immune-suppressive drugs for organ transplants but not typically for transplants in the eye.

Like a few other parts of the body, some components of the eye, like the lens, don't have direct access to vessels that deliver immune cells. They were assumed to be places that immune cells couldn't go. They were immune privileged. But new research suggests that assumption is false - a finding that has implications for both wound healing in the eye and for changes in vision like cataracts. The results were recently published in the Nature journal Scientific Reports.


The finding came as something of a surprise to senior author Sue Menko, PhD, Professor in the Department of Pathology, Anatomy and Cell Biology at Thomas Jefferson University, in part because she hadn't set out to challenge the scientific dogma in the field.

Dr. Menko, together with first author Caitlin Logan, MD, PhD, and second author Caitlin Bowen, was looking at a mouse that had been engineered to stop producing a key developmental protein called N-cadherin just as the lens was beginning to form. Not only did they show that N-cadherin was necessary for creating the perfectly clear structure of the lens, they also observed that malformed lenses lacking N-cadherin began to attract immune cells to try to fix the damage.

The immune cells appear to travel to the lens via a web of ligaments that suspends the lens and connects it to the surrounding muscle tissue called the ciliary body, rich with immune-cell-carrying blood vessels. The main function of the ciliary body is to control the shape of the lens and help us focus.

"Understanding that the lens is accessible to both immune protection and overreaction, could change the way we think about a number vision disorders," says Dr. Menko. "The immune system plays such a major role in many disease states. It's time we began to learn about its role in fibrotic scarring of the lens in cataract formation and other diseases."

Source: Eurekalert

News A-Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Nervous Tic Eye Vision LASIK Surgery Facts Allergy Eye Drops Myasthenia Gravis Routine Eye Examination Quiz On Eye Donation Floppy Iris Syndrome Eyelid Bump 

Recommended Reading
Horrific New Disease Makes Blood to Ooze from the Eyes
A nine-year-old girl died after developing signs related to the Crimean Congo Hemorrhagic Fever ......
Eyelid Cancer Have Risen Steadily Over Past 15 Years
Men were almost twice as likely as women to be diagnosed with squamous cell carcinoma....
In Sync Movement of the Eyes and the Eardrums
The eyes and ears team up to interpret the sights and sounds around us by moving in sync with each ....
Recreation Related Eye Injuries Have Increased Among Kids
The two most common sports and recreation activities associated with eye injury are basketball and ....
Allergy Eye Drops
Eye allergies are treated with different types of eye drops such as lubricants, antihistamines, NSAI...
Eyelid Bump
Our eyelids protect our eyes and keep them moist. Swelling of the eyelid may be localized due to cha...
Floppy Iris Syndrome
Floppy iris syndrome is associated with a high risk of complications following cataract surgery....
Myasthenia Gravis
Myasthenia gravis is the commonest disorder of neuromuscular transmission. Autoimmune myasthenia gra...
Nervous Tic
Trigeminal Neuralgia or tic douloureux is one of the most painful nervous system disorders that affe...
Routine Eye Examination
A comprehensive eye exam can take an hour or more, depending on the doctor and the number and comple...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use