A vital evidence for a potential new approach to treat cognitive impairments in schizophrenia has been revealed thro' a new study.
Schizophrenia is considered one of the most devastating of the major psychiatric disorders, which has three distinct facets, often referred to as "positive" (hallucinations, delusions), "negative" (blunted emotions, reduced capacity for pleasure), and "cognitive" (impairments in attention, memory, and problem-solving) symptoms.
The medications currently approved to treat schizophrenia block a subclass of dopamine receptors (dopamine D2 receptors). They have limited efficacy in treating the negative and cognitive symptoms of this disorder and they are frequently associated with significant side effects. "Hence, there is an acute need to develop alternative treatments for schizophrenia that have fewer side effects and are more effective in treating cognitive and negative symptoms of the disorder," according to the authors of this study, scheduled for publication in Biological Psychiatry on October 1st.
Dr. Moghaddam comments, "This work is significant because it shows that in an awake behaving mammal (as opposed to in tissue cultures or similar preparation), activation of these receptors has a normalizing effect on the spontaneous activity of prefrontal cortex neurons." John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, adds, "These exciting new data provide important new evidence supporting the testing of mGluR5 stimulating medications for the treatment of schizophrenia, particularly cognitive deficits associated with impairments in the function of the prefrontal cortex. It would be very interesting to know whether this class of medication reduces the transient impairments in cognitive function associated with the administration of NMDA receptor blockers to humans." Although the authors acknowledge that much more research is needed to evaluate the clinical impact of this treatment approach, this study indicates a "promising therapeutic potential" that could ultimately result in making improved treatments available to patients struggling with this illness.