Several studies have reported that men have a greater risk of heart attacks than women of similar age. This could be true as a new study reports that testosterone, a male hormone may trigger heart disease risk. The study was funded by the British Heart Foundation (BHF) and the Biotechnology and Biological Sciences Research Council (BBSRC). The findings, published in the journal Scientific Reports, could lead to new therapies to help reduce heart attack risk.
‘Testosterone may trigger calcification in people undergoing androgen replacement therapy, possibly putting them at an increased risk of heart attack and stroke.
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Each year in the UK 188,000 people visit hospital whilst suffering from a heart attack, which is around one person every three minutes. Scientists at the University of Edinburgh examined the effects of testosterone on blood vessel tissue from mice. They found that the hormone triggers cells from the blood vessels to produce bone-like deposits - a process called calcification. When the mouse cells were modified, by removing the testosterone receptor, so they could no longer respond to testosterone, they produced far less of the calcium deposits.
The team also looked at blood vessel and valve tissue from people with heart disease who had undergone surgery for their condition. They found that cells from these tissues contained bone-like deposits and also carried the testosterone receptor on their surface. This suggests that testosterone may trigger calcification in people.
Calcification causes blood vessels to harden and thicken, which means the heart has to work harder to pump blood around the body. It is strongly linked to increased risk of heart attack and stroke. Calcification can also affect the heart's valves, meaning that the valves cannot open and shut properly and may need to be replaced.
Little is known about what triggers calcification and there are currently no treatments. The research team now hope to drill down into the exact mechanism behind this process.
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Dr Vicky MacRae, of the University of Edinburgh's Roslin Institute, said: "Calcification is particularly difficult to treat, as the biological processes behind the disease are similar to those used by our body to make and repair bone. By finding this link between testosterone and calcification we may have discovered a new way of treating this disease and also reducing heart disease."
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Source-Newswise