New research into the processes that control brain cell production could harbinger treatments for brain cancer and other brain-related disorders.
Scientists have gained new understanding of the role played by a key molecule that controls how and when nerve and brain cells are formed - a process that allows the brain to develop and keeps it healthy. Their findings could help explain what happens when cell production goes out of control, which is a fundamental characteristic of many diseases including cancer.
Scientists have gained new understanding of the role played by a key molecule that controls how and when nerve and brain cells are formed - a process that allows the brain to develop and keeps it healthy. Their findings could help explain what happens when cell production goes out of control, which is a fundamental characteristic of many diseases including cancer.
Researchers have focused on a RNA molecule, known as miR-9, which is linked to the development of brain cells, known as neurons and glial cells. They have shown that a protein called Lin28a regulates the production of miR-9, which in turn controls the genes involved in brain cell development and function.
They found that in embryonic cells, Lin28a prevents production of miR-9 by triggering the degradation of its precursor molecule. In developed brain cells, Lin28a is no longer produced, which enables miR-9 to accumulate and function. In cancer cells, Lin28a production is re-established, and as a result this natural process is disrupted.
Researchers used a series of lab tests to unravel the complex processes that are directed by the Lin28a protein. They say further studies could help explain fully the role of Lin28a and miR-9 in brain development, and pave the way to the development of novel therapies.
Dr Gracjan Michlewski of the School of Biological Sciences, who led the study, said: "Understanding more of the complex science behind the fundamental processes of cell development will helps us learn more about what happens when this goes wrong - and what might be done to prevent it."
Source: Eurekalert
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