About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Tale of 2 Prognoses in Pediatric Brain Tumor

by Bidita Debnath on June 4, 2014 at 10:50 PM
Font : A-A+

 Tale of 2 Prognoses in Pediatric Brain Tumor

In the BRAF gene, Pilocytic astrocytoma (PA) is a primarily pediatric brain tumor caused mainly by mutations.

In fact, there are two specific mechanisms for activation of BRAF implicated in PA formation: by fusion of the gene with nearby gene KIAA1549 (K:B fusion) or by point mutations of the BRAF gene itself. Research presented at the American Society for Clinical Oncology (ASCO) Annual Meeting 2014 used a newly designed test for K:B fusion to show that point mutations lead to a more dangerous form of the disease than does K:B fusion.

Advertisement

"Overall, the prognosis for Pilocytic astrocytoma is fairly good. But then we see about 10 percent of cases in which the disease acts more aggressively. What we show is that the non-aggressive and aggressive forms of the disease are, in fact, created by related but distinctly different genetic abnormalities," says Marileila Garcia, PhD, investigator at the University of Colorado Cancer Center and professor at the CU School of Medicine.

The test developed by Garcia for the current study used fluorescent in situ hybridization (FISH) to visualize BRAF and its fusion partner KIAA1549 inside cells, allowing researchers to see when these genes were fused together and when they were apart. In 64 patient samples, Garcia and colleagues found 37 that were K:B fusion positive and 27 that were negative. These two patient populations were markedly different. The mean age of the K:B fusion population was 7.4 years old, compared to 15.2 years old in the non-K:B population; 73 percent of the K:B PAs were found in the cerebellum, whereas 78 percent of the non-K:B PAs were found elsewhere; and non-K:B PAs were much more likely associated with co-occurrence of the disease Type 1 Neurofibromatosis, which can lead to the formation of additional tumors.
Advertisement

The distinction between these two pathways may help to explain the difference between outcomes for younger and older patients - PA in younger patients is more likely to be caused by K:B fusion and 5-year survival is generally high; PA in older patients is more likely to be caused by BRAF point mutations and 5-year survival is generally lower.

"Now that we have a reliable method for detecting K:B fusions in these patients, we may be able to more reliably decide how to treat PA. Patients without K:B fusions have a poor prognosis and should be treated most aggressively," Garcia says.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Parkinsons Disease Surgical Treatment Brain Tumor Brain Tumors Brain Tumor Markers For Cancer Diagnosis and Prognosis Brain Facts Ataxia Pediatric Pyloric Stenosis Language Areas in The Brain 

Recommended Reading
Deep, Integrated Genomic Analysis Re-classified in Lower-grade Brain Tumors
Comprehensive genomic analysis of low-grade brain tumors sorts them into three categories, one of .....
Tiny, Biodegradable Nanoparticles can Carry DNA to Brain Tumor Cells
Johns Hopkins neurosurgeons and biomedical engineers report that they have created tiny, ......
Cancer-Killing Viruses can Help Kill Brain Tumor in Mice
At Massachusetts General Hospital, Harvard Stem Cell Institute (HSCI) scientists have found a ......
UAB Developed Viral Therapy Shows Promise Against Brain Tumors: Study
Researchers report a genetically engineered herpes simplex viral therapy is safe when used in ......
Ataxia
Ataxia affects coordination. Gait becomes unstable and the patient loses balance. The cerebellum or ...
Brain Tumor
Brain tumors are the abnormal growth of brain cells that may be benign or metastatic. Brain tumors a...
Language Areas in The Brain
The mechanism of how human brain processes the language to express and comprehend the verbal, writte...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Pediatric Pyloric Stenosis
Pyloric stenosis in a child is narrowing of the pylorus due to which the milk cannot pass into the s...
Tumor Markers For Cancer Diagnosis and Prognosis
An ideal tumor marker for a cancer should be specific to that cancer and not generate false positive...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use