‘T-cells identify invading viruses and bacteria and can keep a “memory” of previous infections in order to launch a rapid immune response when the body comes under a repeat attack.’
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T-cell therapy works best on the “liquid” tumors of the blood and bone marrow. Scientists believe its strength lies in the fact that T-cells can live and proliferate within the body for months or even years after they have been transfused back into patients. T-cells form an important arsenal in the body’s immune defenses. They help to identify invading viruses and bacteria and can keep a “memory” of previous infections in order to launch a rapid immune response when the body comes under a repeat attack.
Acute Lymphoblastic Leukemia - Incidence Causes Symptoms Diagnosis Treatment Prognosis
Acute lymphoblastic leukemia (ALL) is the cancer of white blood cells characterized by excess lymphoblasts. It is the most common of all childhood cancers and can be fatal in weeks if left untreated.
Acute lymphoblastic leukemia (ALL) is the cancer of white blood cells characterized by excess lymphoblasts. It is the most common of all childhood cancers and can be fatal in weeks if left untreated.
Various trials have been conducted to ensure the effect and feasibility of the treatment. In one trial of a patient’s own T-cells – a type of white blood cell – that were engineered in the laboratory to identify and attack tumor cells, more than 90 percent of the 35 patients with acute lymphoblastic leukemia went into complete remission.
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Acute Myeloid Leukemia-Causes-Symptoms-Diagnosis-Treatment-Prognosis-FAQs
Acute myeloid Leukemia, more popularly known by its abbreviated form AML, is a fast- evolving leukemia that affects both children and adults alike
Acute myeloid Leukemia, more popularly known by its abbreviated form AML, is a fast- evolving leukemia that affects both children and adults alike
In two other clinical trials involving about 40 patients with either non-Hodgkin’s lymphoma or chronic lymphocyte leukemia, more than 80 percent of patients responded to the treatment.
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Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia (CLL) is one of the most common types of adult leukemia and is considered as one of the ‘good cancers’.
Chronic Lymphocytic Leukemia (CLL) is one of the most common types of adult leukemia and is considered as one of the ‘good cancers’.
“In the laboratory and in clinical trials, we are seeing dramatic responses in patients with tumrs that are resistant to conventional high-dose chemotherapy,” said Dr Stanley Riddell, of the Fred Hutchinson Cancer Research Centre in Seattle.
Dr Riddell’s team has developed a method of making chimaeric antigen receptor (CAR) T-cells that are highly stable and consistent, which lowers the risk of a toxic reaction, known as a cytokine storm, which can result in fatal fevers and falls in blood pressure.
“Our approach has been to try to formulate a T-cell product of defined composition in every patient, so it is the same in every patient. It removes a big variable,” said Dr Riddell. “These cells have the capacity to proliferate. They have the capacity to survive long term as memory cells, and they have the capacity to differentiate to the effective lineages that are necessary to mediate anti-tumor activity.”
Source-Medindia
