About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Systemic Sclerosis is an Independent Risk Factor for Atherosclerosis, Says Study

by Kathy Jones on May 12, 2011 at 9:33 PM
Font : A-A+

 Systemic Sclerosis is an Independent Risk Factor for Atherosclerosis, Says Study

Systemic sclerosis is an independent determinant for moderate to severe coronary calcification or atherosclerosis, says a new study by researchers in Hong Kong.

Conventional cardiovascular risk factors such as age and hypertension predispose patients with systemic sclerosis to plaque build-up in the heart arteries similar to the general population. Details of this study are now available in Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology (ACR).

Advertisement

Systemic sclerosis, also known as scleroderma, is a connective tissue disease which is characterized by sclerodermatous (hardening of tissue due to increased collagen deposits) skin changes, Raynaud's phenomenon, and internal organ fibrosis. The ACR estimates that systemic sclerosis affects 49,000 Americans and a prior U.S. study approximated the prevalence to be 25 per 100,000 individuals. While medical evidence suggests that coronary artery disease (CAD) is increasing in patients with systemic sclerosis, the prevalence of coronary calcification (a measure of coronary artery atherosclerosis) and its risk factors remain unknown.

In the current study a research team, led by Dr. Mo Yin Mok of the Queen Mary Hospital and the University of Hong Kong, recruited 53 patients with systemic sclerosis (50 female, 3 male) and 106 healthy controls to examine coronary artery calcium scores (CACS) and cardiovascular risk factors. Disease activity score, antiphospholipid antibodies, C-reactive protein, and erythrocyte sedimentation rate were also measured for scleroderma patients.
Advertisement

Researchers found that 57% of patients with systemic sclerosis had moderate to severe coronary calcification (CACS greater than 101) compared to only 29% of controls. Scleroderma patients also had significantly lower LDL-cholesterol, HDL-cholesterol, and diastolic blood pressure compared to healthy controls. In addition, compared to the control group, roughly one-third of patients had a low body mass index (BMI) and would be considered underweight according to recommended BMI cutoffs for Asian populations.

Regression analysis also showed that systemic sclerosis was an independent risk factor for coronary artery calcification (odds ratio of 10.89), and disease duration was associated with more severe atherosclerosis. The results of this study concur with previous reports of increased atherosclerosis as determined by angiography in patients with systemic sclerosis. "Our findings show that systemic sclerosis patients have an 11-fold increased risk for developing moderate to severe coronary calcification after adjustment for normal cardiovascular risk factors," concluded Dr. Mok. "CAD is a major global health concern, and further studies should explore modifiable disease-specific risk factors in scleroderma patients that could inhibit coronary calcification in this population."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
COVID Toes
International Yoga Day 2022 - 'Yoga for Humanity'
Wearable Devices Are Now Transforming Depression, Multiple Sclerosis, and Epilepsy Management.
View all
Recommended Reading
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Atherosclerosis 

Most Popular on Medindia

The Essence of Yoga Drug - Food Interactions Calculate Ideal Weight for Infants Daily Calorie Requirements Color Blindness Calculator Nutam (400mg) (Piracetam) Drug Side Effects Calculator Sinopril (2mg) (Lacidipine) Turmeric Powder - Health Benefits, Uses & Side Effects Pregnancy Confirmation Calculator

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE