About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Switching Patients on One Type of Antiretroviral Therapy (ART) to Another Not Beneficial

by Savitha C Muppala on July 19, 2012 at 5:45 PM
Font : A-A+

 Switching Patients on One Type of Antiretroviral Therapy (ART) to Another Not Beneficial

A increasingly used type of HIV study which involves switching patients on one type of antiretroviral therapy (ART) to another, to see whether the new drug is as good as the at preventing replication of the HIV virus, may be unethical, according to a new Essay published in this week's PLoS Medicine. The studies, termed non-inferiority trials, are only ethical if participants can meaningfully benefit from the treatment change and are more likely to benefit than suffer harm, according to Andrew Carr from the HIV unit in St Vincent's Hospital in Sydney, Australia, Jennifer Hoy from the infectious diseases unit in Alfred Hospital in Melbourne, Australia, and Anton Pozniak from the Chelsea and Westminster Hospital in London, UK. The authors argue in their essay that such trials are not in the best interests of patients, especially as often, these trials have inadequate numbers to assess the key expected benefit and reports all outcomes.

The authors say: "There are several potential advantages and disadvantages for patients of switching or simplifying ART. Potential advantages include reduced toxicity, pill burden, or cost. One key potential disadvantage is that effective, well-tolerated ART is abandoned."

Advertisement

The authors argue that such trials often enrol patients who cannot benefit with the switch, do not capture or report all potential risks, and are designed with a view to a pharmaceutical company's profits rather than participant benefit. They make a strong case for measuring, analysing and reporting relevant disadvantages of the switch and argue that patients must be informed about all potential advantages and disadvantages.

The authors conclude: "Switching ART regimens when virologically suppressed may be appropriate for many reasons, but the full risk-benefit profile should be determined beforehand. The diminishing antiretroviral drug pipeline suggests greater care will need to be given in coming years to extending the benefits of existing drugs for what is likely to remain lifelong therapy."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Otitis Media Reiki and Pranic Healing Antiretroviral Therapy for HIV Treatment 

Most Popular on Medindia

Daily Calorie Requirements Hearing Loss Calculator Drug - Food Interactions How to Reduce School Bag Weight - Simple Tips A-Z Drug Brands in India Pregnancy Confirmation Calculator Drug Interaction Checker Turmeric Powder - Health Benefits, Uses & Side Effects Selfie Addiction Calculator The Essence of Yoga
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Switching Patients on One Type of Antiretroviral Therapy (ART) to Another Not Beneficial Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests