Switching Off a Protein Can Boost Effectiveness of Cancer Immunotherapies

by Adeline Dorcas on  August 1, 2018 at 4:49 PM Cancer News
RSS Email Print This Page Comment bookmark
Font : A-A+

New study discovered inhibiting a protein can reduce tumor burdens and enhance the effectiveness of immunotherapy treatments. The findings of the study are published in Cancer Discovery.
Switching Off a Protein Can Boost Effectiveness of Cancer Immunotherapies
Switching Off a Protein Can Boost Effectiveness of Cancer Immunotherapies

In order to investigate the role of the Yes-associated protein, or YAP, in T-cells in the cancer setting, scientists used mice genetically engineered to lack YAP in several T-cell populations, including regulatory T-cells, known as Tregs. This was the first time the relationship between YAP and Tregs has been explored.

Tregs are important for health because they prevent autoimmune diseases but can be a major obstacle in the mounting of immune responses to tumors and immunotherapy. YAP can be found in a subset of those regulatory T-cells.

Scientists tested the antitumor effects of YAP inhibitors alone and in combination with immunotherapies. Their encouraging results showed YAP plays a role in the suppression of antitumor immunity by Tregs and demonstrated by turning off YAP's abilities, tumor killing with less restrained immune cells is possible.

Fan Pan, M.D., Ph.D., senior author of the study and associate professor of cancer immunology, said blocking YAP or the signaling pathways under its control boosted the effects of both a tumor vaccine and a checkpoint inhibitor (anti-PD1 antibody) to produce even stronger antitumor activity. He said the approach of therapeutically targeting YAP was effective over a broad scope of cancer types in mice.

Since Tregs are notorious for dampening the effectiveness of tumor-directed immunity in cancer patients, this study's finding may pave the way for a new and promising strategy to unleash the patient immune response from the stifling grip of suppressor cell control.

While Pan and study authors are optimistic that further work could lead to effective YAP-targeting immunotherapies for cancer, they pointed out therapies aimed at enhancing YAP activity may have potential use for the treatment of autoimmune diseases.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions
Advertisement

Recommended Reading

More News on:

Cancer and Homeopathy Cancer Facts Cancer Tattoos A Body Art Amyotrophic Lateral Sclerosis (ALS) Magical Millets for Your Health The Basics of Baby Food Diet and Nutrition Tips for Athletes Nutrition IQ Common Lifestyle Habits that Cause Diseases 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive