About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Survival Terms can be Judged by Subtyping Breast Cancer by Immunohistochemistry

by Kathy Jones on May 26, 2010 at 6:52 PM
Font : A-A+

 Survival Terms can be Judged by Subtyping Breast Cancer by Immunohistochemistry

A new study has evaluated immunohistochemistry-based subtype classification of breast tumors for the prediction of disease outcome. The study by Paul Pharoah and colleagues is published in this week's PLoS Medicine

Their analysis is based on more than 10,000 breast cancer cases with early disease, and examines the influence of a patient's tumour type on the prediction of future survival.

Advertisement

As has been shown previously the three subtypes of ER negative disease have a poorer outcome than the ER positive disease subtypes in the short term. However, this study has shown that in the long term, the ER negative disease subtypes have a better prognosis. This study has also conclusively demonstrated that the so-called triple negative tumours (ER-, PR- and HER2-) can be divided into two sub-types (basal and non-basal) with the basal subtype having a poorer prognosis.

The observed survival patterns were independent of any systemic adjuvant therapy, suggesting that tumour biology and molecular heterogeneity within breast cancer subtypes, rather than the choice of therapy, determined the survival trends. The authors recommend that this prognostic method should be incorporated into clinical practice.

A related Perspective by Stefan Ambs in the same issue examines the clinical significance of this large study and discusses the limitations of subtype classification for prognostication and targeted therapy in the management of breast cancer.



Source: Eurekalert
RAS
Advertisement
Advertisement

Recommended Reading

open close
CONSULT ONLINE WITH A DOCTOR

×

Survival Terms can be Judged by Subtyping Breast Cancer by Immunohistochemistry Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests