Survival for African-Americans With Throat Cancer Improves With HPV: Study

Human papillomavirus (HPV) improves survival for African Americans with throat cancer, say researchers.

According to their new study, HPV has a substantial impact on overall survival in African Americans with oropharyngeal cancer, a cancer that affects part of the throat, the base of the tongue, the tonsils, the soft palate (back of the mouth), and the walls of the pharynx (throat).

Cancer of Larynx (Throat Cancer)-Risk Factors-Symptoms-Diagnosis-Treatment
Laryngeal cancer is also called cancer of the larynx or throat cancer or laryngeal carcinoma. It usually affects men over the age of 55 years.

The study shows African Americans who are HPV positive have better outcomes than African Americans without HPV.

Further, African Americans who are HPV negative not only have poorer survival compared to African Americans with HPV, they also did worse than Caucasians both with HPV and without HPV present in oropharyngeal cancer.

"This study adds to the mounting evidence of HPV as a racially-linked sexual behavior lifestyle risk factor impacting survival outcomes for both African American and Caucasian patients with oropharyngeal cancer," says lead author Maria J. Worsham, Ph.D., director of research in the Department of Otolaryngology-Head & Neck Surgery at Henry Ford.

Pap smear and Cervical Cancer Screening
Pap smear is the most common test used in screening cervical cancer caused by an infection with human papilloma virus. Pap smear should be repeated every 1 to 3 years till the age of 65 years.

Study results will be presented Sunday, July 22 at the 8th International Conference on Head & Neck Cancer in Toronto. The research was funded by a National Institutes of Health grant.

The American Cancer Society's estimates about 35,000 people in the U.S. will get oral cavity and oropharyngeal cancers in 2012; an estimated 6,800 people will die of these cancers.

Response to Radiotherapy Alone Better in HPV-Positive Throat Cancer Patients Than HPV-Negative Patients
The role of HPV in throat cancer has been investigated extensively.

Similar to other cancers of the head and neck cancer, risk factors include smoking, alcohol consumption. HPV is also a risk factor for oropharyngeal cancer.

To compare survival outcomes in HPV positive and HPV negative African Americans with oropharyngeal cancer, Dr. Worsham and her team conducted a retrospective study of 118 patients.

Secure Protocol for Linking Data Registries for HPV Surveillance
Monitoring the effectiveness of the HPV vaccine in Canada requires that data from multiple registries and other data sources be combined.

Among the study group, 67 are HPV negative and 51 are HPV positive. Forty-two of those in the study are African American.

The study found that:

African Americans are less likely to be HPV positive
Those older than 50 are less likely to be HPV positive
Those with late-stage oropharyngeal cancer are more likely to be unmarried and more likely to be HPV positive
HPV negative patients had 2.9 times the risk of death as HPV positive patients
Overall, the HPV race groups differed with significantly poorer survival for HPV negative African Americans versus HPV positive African Americans, HPV positive Caucasians and HPV negative Caucasians

Source-Eurekalert