Rafts of fatty lipids on the cell surface act as compartments to keep certain enzymes from mixing with their binding partners.

‘Lipid rafts on live cells did indeed assemble and disassemble frequently, creating opportunities for enzymes to mix with their substrates.’

"This is really different from how anybody thinks about mechanosensation," said TSRI biologist Scott Hansen, who supervised the study, published recently in the journal Nature Communications. 




Hansen compared lipid rafts to compartments in a glow stick. Crack the barrier between the two sides of a glow stick and the components mix and start a chemical reaction to produce light. On the cell membrane, the mixing of enzymes and their partners produces a signaling lipid phosphatidic acid that starts the chain of events to create the sense of touch.
Release the Enzymes!
Hansen and his colleagues conducted this research with support from a National Institutes of Health Director's New Innovator Award, which encourages scientists to pursue high-risk, high-reward translational research. Their mission was to shed light on the complicated cellular mechanisms behind touch with the hope that this work could lead to new ways to address chronic pain and other conditions where the sense of touch goes haywire.
The team focused on lipid rafts, small clumps of lipids and proteins on the cell membrane. Hansen said previous work had explained lipid rafts as "pedestals" of activity, like islands where the cell can carry out important activities. But there was also a question of whether rafts can act like holding pens, keeping enzymes from meeting their binding partners, or substrates, until the right moment.
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While more research is needed, the researchers believe this signal may be picked up by other proteins in the membrane that carry on this message to sense touch. Hansen said it's also likely that other enzymes in lipid rafts are mixing with their substrates in a similar way to regulate cellular responses to many stimuli outside touch. "This is just the first step in understanding this process," said Hansen.
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Source-Eurekalert