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Surgery Increases the Risk of Developing Guillain-Barré Syndrome

by Dr. Meenakshy Varier on November 24, 2016 at 9:46 AM
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Surgery Increases the Risk of Developing Guillain-Barré Syndrome

People who undergo surgery have higher chances of developing Guillain-Barré syndrome (GBS), especially for those suffering from cancer or autoimmune disorders.

The new study, published in the November 23, 2016, online issue of Neurology Clinical Practice, showed that 15% of those who developed the syndrome had a surgical procedure within two months prior to developing the disease.


Guillain-Barré syndrome is a rare muscle disorder in which a person's immune system attacks nerve cells, damaging the peripheral nervous system connecting the brain and spine with the rest of the body.

Symptoms include muscle weakness that can increase in intensity and in some cases lead to total paralysis. When it interferes with breathing, it can become deadly.

"The results of our study were surprising," said study author Sara Hocker, MD, PhD, of the Mayo Clinic in Rochester, Minn., and member of the American Academy of Neurology. "We did not expect to see a higher percentage of patients who developed the syndrome after having surgery."

The research found that having cancer or autoimmune disease may predispose a person to developing Guillain-Barré syndrome after surgery.

For the study, researchers evaluated the medical records of patients treated for Guillain-Barré syndrome at the Mayo Clinic over two decades.

Of the 208 people treated for GBS, 31 people, or 15%, had developed the syndrome within eight weeks of having a surgical procedure.

Researchers found that people with cancer and those with autoimmune disorders were more likely to develop GBS after surgery.

People who had cancer within the past six months were seven times more likely to develop GBS after surgery than those who did not have cancer.

People who had pre-existing autoimmune disorders such as ulcerative colitis or type 1 diabetes were five times more likely to develop GBS after surgery than those without autoimmune disorders.

Source: Medindia
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