Superbug C.Difficile's Genome Unraveled

Scientists from London School of Hygiene and Tropical Medicine and The Wellcome Trust Sanger Institute claim to have unravelled the genome of the most virulent form of hospital superbug

The most virulent form of superbug that has long plagued hospitals, Clostridium difficile, may have just found its match in scientists from London School of Hygiene and Tropical Medicine and The Wellcome Trust Sanger Institute who claim to have unravelled bug's genome.

Lead researcher Brendan Wren from the London School of Hygiene and Tropical Medicine and his colleagues compared the genomes of three strains of the bacterium, the hypervirulent '027' strain, an historic, non-epidemic 027 strain and one less related and also non-epidemic '630' strain.

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"C. difficile is the most frequent cause of nosocomial diarrhoea worldwide. In the past five years a new group of highly virulent C. difficile strains has emerged to cause outbreaks of increased severity in North America and Europe," said Wren.

"Several studies have shown that patients infected with these '027' strains have more severe diarrhoea, higher mortality and more recurrences.

"This study provides genetic markers for the identification of 027 strains and offers a unique opportunity to explain their emergence," he added.

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The researchers found that the 027 strains had considerable genetic differences compared to the non-epidemic 630 strain, which may relate to the observed phenotypic difference in virulence.

In addition, five genetic regions appear to have accumulated over the last 20 years in the modern day epidemic 027 strain, compared to its historic counterpart.

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"The observed gene differences between these strains might individually or collectively explain why modern 027 strains are more likely to be epidemic and could explain the higher case-fatality ratio and persistence associated with infection by these strains," said Wren.

The study appears in BioMed Central's open access journal Genome Biology.

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