Calcium molecules are key in cell function, and are believed to be involved in 'turning down' the sense of smell.

‘Sodium citrate, the sodium salt of citric acid, is safe to use and already licensed for medicinal uses in the stomach and bladder.’

Sodium citrate, the sodium salt of citric acid, is safe to use and already licensed for medicinal uses in the stomach and bladder. 




Sodium citrate is known to bind calcium. Calcium molecules are key in cell function, and are believed to be involved in 'turning down' the sense of smell. Researchers wanted to investigate if reducing calcium in the mucus in the nose would supress its ability to inhibit a person's sense of smell.
Carl Philpott from UEA said: "The sodium citrate nasal spray was designed to 'mop up' calcium molecules in nasal mucus and as a result, temporarily turn up the sense of smell.
"In the randomised trial, patients were treated either with sodium citrate spray or sterile water. They were then invited to take part in a series of tests, smelling increasingly stronger concentrations of four different odours - roses, pear, vinegar and menthol, noting at what concentration they could detect the smell.
"Results showed an improvement in those treated with the spray, which lasted for up to two hours. It seemed to be most effective in people whose ability to smell was damaged by viral infection, called post viral olfactory loss or PVOL."
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Of the patients randomised to be treated with sodium citrate spray, one third showed an improvement with the peak effect seen between 15 and 30 minutes after treatment. Minor side effects noted by patients included a sore throat, slightly runny nose and itching.
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"Further study in the form of larger clinical trials with patients applying the treatment regularly would help inform whether this treatment should be offered routinely by doctors. It could quite easily and safely be formulated into a treatment to provide temporary relief from smell loss, enhancing the quality of life of patients with very few side effects."
Source-Eurekalert