About My Health Careers Internship MedBlogs Contact us

Substance Used to Treat Bladder Issues Could Temporarily Restore Sense of Smell

by Bidita Debnath on April 8, 2017 at 11:04 PM
Font : A-A+

 Substance Used to Treat Bladder Issues Could Temporarily Restore Sense of Smell

A substance commonly used to treat bladder issues could temporarily treat people who have lost their sense of smell, claims a research published in the journal Clinical Otolaryngology.

A study by the University of East Anglia (UEA) with the Smell & Taste clinic at the James Paget University Hospital showed sodium citrate nasal spray could offer temporary improvement in the ability to smell for patients suffering from anosmia or hyposmia -- the loss of smell -- in cases caused by a virus or other non-obstructive causes.


Sodium citrate, the sodium salt of citric acid, is safe to use and already licensed for medicinal uses in the stomach and bladder.

Sodium citrate is known to bind calcium. Calcium molecules are key in cell function, and are believed to be involved in 'turning down' the sense of smell. Researchers wanted to investigate if reducing calcium in the mucus in the nose would supress its ability to inhibit a person's sense of smell.

Carl Philpott from UEA said: "The sodium citrate nasal spray was designed to 'mop up' calcium molecules in nasal mucus and as a result, temporarily turn up the sense of smell.

"In the randomised trial, patients were treated either with sodium citrate spray or sterile water. They were then invited to take part in a series of tests, smelling increasingly stronger concentrations of four different odours - roses, pear, vinegar and menthol, noting at what concentration they could detect the smell.

"Results showed an improvement in those treated with the spray, which lasted for up to two hours. It seemed to be most effective in people whose ability to smell was damaged by viral infection, called post viral olfactory loss or PVOL."

The loss of smell can have a significant impact on sufferers. It can often lead to reduced intake of nutritional food and weight loss as well as affecting personal relationships, social enjoyment and having a negative impact on psychological wellbeing.

Of the patients randomised to be treated with sodium citrate spray, one third showed an improvement with the peak effect seen between 15 and 30 minutes after treatment. Minor side effects noted by patients included a sore throat, slightly runny nose and itching.

Philpott said: "This study offers proof of concept that sodium citrate spray may enhance a damaged sense of smell in patients with partial loss of smell not caused by obstructions.

"Further study in the form of larger clinical trials with patients applying the treatment regularly would help inform whether this treatment should be offered routinely by doctors. It could quite easily and safely be formulated into a treatment to provide temporary relief from smell loss, enhancing the quality of life of patients with very few side effects."

Source: Eurekalert

News A-Z
News Category
What's New on Medindia
Ten Fruits for Diabetics
Natural Supplements Help Reverse Hair Loss during Menopause
Ways to Manage Stress during COVID-19 Pandemic
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Anosmia Vesico-Ureteric Reflux Causing UTI in Children Enuresis/Bedwetting Interstitial Cystitis Bladder Cancer 

Recommended Reading
Why Some People can Smell Asparagus in Urine?
The genetic origin of the ability to smell the strong, characteristic odor in human urine produced ....
Smell Test can Reveal Risk of Alzheimer's Disease
An odour identification test can tell whether or not your loved one is at risk of Alzheimer's ......
New Partnership to Study Link Between Ability to Smell and Neurodegenerative Diseases
Deterioration in a person's ability to smell can sometimes be an early sign of neurodegenerative ......
NOSE App Alerts When You Smell Bad
Summer heat makes us sweat a lot than the usual and we are so used to our own body odor that we ......
Anosmia is the inability to perceive smell. Most patients with anosmia complain of losing the sense ...
Bladder Cancer
Bladder cancer occurs due to abnormal cell growth in the urinary bladder. The most common kind usual...
Bedwetting (nocturnal enuresis) is involuntary voiding of urine during sleep at least three times a ...
Interstitial Cystitis
Interstitial cystistis is an umbrella term where a pathology cannot be defined but the patient suf...
Vesico-Ureteric Reflux Causing UTI in Children
Bacterial infection of urinary bladder can cause pain and burning sensation while passing urine. Abn...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use