Pancreatic cancer, the uncontrollable cell growth in the pancreas, is one
of the most lethal malignancies reported in the world. This is due to its late
diagnosis and limited response to treatment. The risk of the cancer is manifold
as there are no available prognosis methods to start treating pancreatic cancer
early, so that the patient's life could be saved.
Hence, tractable methods to identify and interrogate the pathways that are involved in the process of the creation of pancreatic tumor are urgently needed. Scientists have newly developed organoid models, which are miniature organs, grown in vitro, from normal and neoplastic murine and human pancreas tissues in a new study addressing this issue. Pancreatic organoids have the advantage of being generated from rejected tumors and biopsies, survive cryo-preservation and exhibit ductal- and disease-stage-specific characteristics.
The neoplastic organoids when orthotopically transplanted to the apt place, reiterate the full spectrum of tumor development by forming early-grade neoplasms that progress to locally invasive and metastatic carcinomas. The organoids are a platform to probe genetic cooperation, due to their ability to be genetically manipulated. A Comprehensive transcriptional and proteomic analysis of the murine pancreatic organoids has revealed genes and pathways altered during the progression of the cancer. It was found by the researchers that the confirmation of many of these protein changes in human tissues demonstrates that organoids are a simplistic model system to discover characteristics of the deadly pancreatic cancer malignancy.