Pancreatic cancer, the uncontrollable cell growth in the pancreas, is one
of the most lethal malignancies reported in the world. This is due to its late
diagnosis and limited response to treatment. The risk of the cancer is manifold
as there are no available prognosis methods to start treating pancreatic cancer
early, so that the patient's life could be saved.
Hence, tractable methods to identify and interrogate the pathways that are
involved in the process of the creation of pancreatic tumor are urgently
needed. Scientists have newly developed organoid models, which are miniature
organs, grown in vitro, from normal and neoplastic murine and human pancreas
tissues in a new study addressing this issue. Pancreatic organoids have the
advantage of being generated from rejected tumors and biopsies, survive
cryo-preservation and exhibit ductal- and disease-stage-specific
characteristics.
Pancreatic Cancer
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. Treatment options include surgery, radiation and chemotherapy.
The neoplastic organoids when orthotopically transplanted to the apt place, reiterate the full spectrum of tumor development by forming early-grade neoplasms that progress to locally invasive and metastatic carcinomas. The organoids are a platform to probe genetic cooperation, due to their ability to be genetically manipulated. A Comprehensive transcriptional and proteomic analysis of the murine pancreatic organoids has revealed genes and pathways altered during the progression of the cancer. It was found by the researchers that the confirmation of many of these protein changes in human tissues demonstrates that organoids are a simplistic model system to discover characteristics of the deadly pancreatic cancer malignancy.
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 New Method That Lets an Earlier Diagnosis of Pancreatic Cancer DevelopedResearchers have devised a new method than allows an earlier diagnosis of pancreatic cancer. | Advertisement
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Fatty Foods Speed Up Pancreatic Cancer
In a recent study UCLA scientists claim that a fatty diet can speed up the onset of pancreatic cancer.
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