About Careers MedBlog Contact us

Study Uses Organoids to Learn About the Stages of Pancreatic Cancer

by Kalyani Thivakaran on January 5, 2015 at 6:15 PM
Font : A-A+

 Study Uses Organoids to Learn About the Stages of Pancreatic Cancer

Pancreatic cancer, the uncontrollable cell growth in the pancreas, is one of the most lethal malignancies reported in the world. This is due to its late diagnosis and limited response to treatment. The risk of the cancer is manifold as there are no available prognosis methods to start treating pancreatic cancer early, so that the patient's life could be saved.

Hence, tractable methods to identify and interrogate the pathways that are involved in the process of the creation of pancreatic tumor are urgently needed. Scientists have newly developed organoid models, which are miniature organs, grown in vitro, from normal and neoplastic murine and human pancreas tissues in a new study addressing this issue. Pancreatic organoids have the advantage of being generated from rejected tumors and biopsies, survive cryo-preservation and exhibit ductal- and disease-stage-specific characteristics.


The neoplastic organoids when orthotopically transplanted to the apt place, reiterate the full spectrum of tumor development by forming early-grade neoplasms that progress to locally invasive and metastatic carcinomas. The organoids are a platform to probe genetic cooperation, due to their ability to be genetically manipulated. A Comprehensive transcriptional and proteomic analysis of the murine pancreatic organoids has revealed genes and pathways altered during the progression of the cancer. It was found by the researchers that the confirmation of many of these protein changes in human tissues demonstrates that organoids are a simplistic model system to discover characteristics of the deadly pancreatic cancer malignancy.

Source: Medindia


Recommended Reading

Latest Cancer News

Why Is Time of Day Important in Cancer Diagnosis and Treatment?
Chronotherapy (the sleep-wake cycle) is observed as a valuable alternative treatment in cancer diagnosis and treatment.
How Do Neutrophils Impact Pancreatic Cancer Treatment Resistance?
A nanoengineering platform targets neutrophils, the white blood cells without killing pancreatic cancer cells paving the way for effective treatments.
Lung Cancer: The Survival Advantage of Lobectomy Over Wedge Resection
The survival rates between lobectomy and wedge resection surgical procedures were found to be the same among lung cancer patients.
Could TKI Cancer Drugs Lead to Inflammatory Side Effects?
The mechanism by which the kinases cause inflammation has been discovered by scientists.
Are Biomarkers the Key to Identifying Early Pancreatic Risk?
Pancreatic cancer cases are on the rise. The biomarker approach could reduce the chance of developing pancreatic cancer.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Study Uses Organoids to Learn About the Stages of Pancreatic Cancer Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests