About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Study Uncovers Factors That Cause Melanoma Metastasis

by Anjali Aryamvally on May 2, 2018 at 5:15 PM
Font : A-A+

Study Uncovers Factors That Cause Melanoma Metastasis

Melanoma is one of the few cancers for which mortality has stabilized or even increased. The reason for this is its ability, in later stages, to spread to other parts of the body. New study uncovers the critical factors in the tumor lymphatic microenvironment that promote the melanoma cell distant organ metastasis.

Melanoma is considered metastatic - also called Stage IV melanoma - when the cancer cells have spread through the lymph nodes to distant sites in the body, the most often affected being liver, lungs, bones and brain.

Advertisement


Often primary melanomas grow and spread horizontally on the top layer of the skin before penetrating deeper into the layers of the dermis where they can reach the lymph and blood vessels. Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma.

In addition to providing a direct route for dissemination, the lymph vessels have been proposed to directly modulate the metastatic process through mechanisms that have remained elusive.
Advertisement

"Because the mechanisms and functional contribution of lymphatic dissemination in distant organ melanoma metastasis remain incompletely understood, we have investigated the contribution of the cells that form the walls of the lymphatic vessels, the lymphatic endothelial cells, to human melanoma cell invasion and metastasis", tells Professor Päivi Ojala from the University of Helsinki, Finland. She continues:

"In particular, our goal was to uncover the critical factors in the tumor lymphatic microenvironment that promote the melanoma cell distant organ metastasis and thereby to generate new leads and potential targets to more efficient treatments and prognosis for metastatic cancer."

Growing human melanoma cells in co-cultures with human primary lymphatic endothelial cells increased the invasive growth of melanoma cells in cell culture conditions that mimick the tissue environment and facilitated melanoma distant organ metastasis in mice implanted with human melanoma cells. This lymphatic endothelium mediated change in the melanoma was dependent on MMP14, Notch3 and 1-integrin proteins, and MMP14 and Notch3 were necessary for the increased metastasis of human melanoma cells in a zebrafish tumor model.

The study uncovers a unique mechanism whereby the direct contact with lymphatic endothelial cells promotes melanoma metastasis.

"These findings can represent new leads that clinicians can consider as prognostic markers for metastasis and the pharmaceutical industry can pursue for further therapeutics development", Professor Ojala says.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Skin Cancer Ultra-Violet Radiation Melanoma 

Recommended Reading
Melanoma Skin Cancers Linked With Reduced Risk of Alzheimer's Disease
Diagnosis of malignant melanoma (skin cancer) was associated with a 61% reduced risk of developing ....
Attacking Melanoma With a Combination Therapy
Study findings have implications for treating tumors lacking tumor suppressor gene PTEN....
Novel Therapeutic Strategy to Treat Melanoma
Combination therapy co-targeting the mitochondria enhances the antitumor effect of telomerase ......
New Treatment Could Keep Melanoma at Bay
Changing schedules of drug administration for melanoma can improve outcomes leading to more ......
Melanoma
Melanoma is a dangerous form of skin cancer caused largely due to exposure to the sun’s damaging UV ...
Skin Cancer
Skin cancer is an abnormal growth of skin cells. It can develop due to a continuous exposure to sun ...
Ultra-Violet Radiation
Ultraviolet radiations are electromagnetic radiations with wavelengths shorter than the shortest wav...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use