Birth size, or the birth length, of a person can act as an indicator of subsequent risk of breast cancer in adulthood, cites a new study by researchers at the London School of Hygiene and Tropical Medicine.
Led by Isabel dos Santos Silva (Professor of Epidemiology), the researchers re-analysed data from published and unpublished studies to get more precise estimates of the extent to which birth size affects the risk of breast cancer later in life.
Breast Self Examination - Animation
Slides and animation of Breast Self Examination for early detection of breast cancer lumps in women
Advertisement
They also wanted to investigate whether associations with other risk factors could explain the estimates.
After analysing 32 studies, comprising 22,058 cases of breast cancer among a total of more than 600,000 women mainly from developed countries, the researchers found that birth weight was positively associated with breast cancer risk in studies where information on birth size was based on birth records (although not in those based on adult self-reports, which tend to be less accurate).
![Ideal Baby Weight]( "Ideal Baby Weight")
The study of data from birth records showed that a 0.5 kg increment in birth weight was associated with an estimated 7 percent increase in the risk of breast cancer.
When studies with data from birth records were analysed, the researchers found that birth length and head circumference were positively linked with breast cancer risk. Out of the three birth size measures examined, birth length appeared to be the strongest independent predictor of risk.
However, when the effects of established breast cancer risk factors were accounted for, the estimated magnitude of the birth size association with breast cancer risk was not affected.
"Our study indicates that birth size is a marker of susceptibility to breast cancer in adulthood, at least in developed countries. The birth size - breast cancer association appeared to be largely independent of known risk factors. Little is known on how the pre-natal environment may affect breast cancer risk later in life. Further research is needed to unravel the biological mechanisms underlying the birth size - breast cancer association," said Isabel dos Santos Silva.
The study was published in PLoS Medicine.
Source: ANI
SRM
Advertisement
The study of data from birth records showed that a 0.5 kg increment in birth weight was associated with an estimated 7 percent increase in the risk of breast cancer.
When studies with data from birth records were analysed, the researchers found that birth length and head circumference were positively linked with breast cancer risk. Out of the three birth size measures examined, birth length appeared to be the strongest independent predictor of risk.
However, when the effects of established breast cancer risk factors were accounted for, the estimated magnitude of the birth size association with breast cancer risk was not affected.
"Our study indicates that birth size is a marker of susceptibility to breast cancer in adulthood, at least in developed countries. The birth size - breast cancer association appeared to be largely independent of known risk factors. Little is known on how the pre-natal environment may affect breast cancer risk later in life. Further research is needed to unravel the biological mechanisms underlying the birth size - breast cancer association," said Isabel dos Santos Silva.
The study was published in PLoS Medicine.
Source: ANI
SRM
Advertisement
Advertisement
|
Advertisement
Recommended Readings
Latest Cancer News
The new study uncovers the efficacy of fixed-duration combination treatment in patients with high-risk leukemia.
The approvals of pipeline drugs such as momelotinib and Vonjo for myelofibrosis (a rare type of blood cancer) over some time will handle the critical unmet needs.
New study highlights the dual role that blood vessels can play in cancer immunotherapy and eliciting anti-tumor immune responses or even preventing breast cancer spread.
New study evaluated the association between exposure to the chemical agent orange and the development of blood cancer with increased bleeding and blood clot formation.
Study suggests two-year immunotherapy treatment for advanced lung cancer may be reasonable