Notch-1 expression is increased in the hippocampus of Alzheimer's disease patients, suggest recent studies.
Huimin Liang and co-workers from Second Affliated Hospital of Zhengzhou University, China speculate that Notch-1 signaling may be involved in PC12 cell apoptosis induced by amyloid beta-peptide (25-35) (Aβ25-35).
Risk Factors for Alzheimers Disease
Cognitively normal adults exhibiting atrophy of their temporal lobe or damage to blood vessels in the brain are more likely to develop Alzheimer's disease.
Advertisement
In a study reported on the Neural Regeneration Research (Vol. 9, No. 13, 2014), PC12 cells were cultured with different doses (0, 0.1, 1.0, 10 and 100 nmol/L) of N-[N-(3,5-Difuorophen-acetyl)-L-alanyl]-S-phenylglycine t-butyl ester, a Notch-1 signaling pathway inhibitor, for 30 minutes.
Then cultured cells were induced with Aβ25-35 for 48 hours. Pretreatment of PC12 cells with high doses of N-[N-(3,5-Difuorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (> 10 nmol/L) prolonged the survival of PC12 cells after Aβ25-35 induction, decreased the expression of apoptosis-related proteins caspase-3, -8, -9, increased the activity of oxidative stress-related superoxide dismutase and catalase, inhibited the production of active oxygen, and reduced nuclear factor kappa B expression.
This study indicates that the Notch-1 signaling pathway plays a pivotal role in Aβ25-35-induced PC12 apoptosis.
Source: Eurekalert
This study indicates that the Notch-1 signaling pathway plays a pivotal role in Aβ25-35-induced PC12 apoptosis.
Source: Eurekalert
Young Blood to Cure Decline of Aging Brain
A research showed that injections of juvenile mouse blood boosts learning and memory in older rodents, findings that hold the long-sought cure for the decline of ageing brain.
Advertisement
 Smokers are at Risk of Alzheimer's DiseasePeople who smoke are at a greater risk of developing Alzheimer's disease and other forms of dementia. | Advertisement
|
Mice Breed Used In Alzheimer’s Disease Research Not That Effective
Scientists opine that recently developed mouse breeds that mimic the symptoms of Alzheimer's disease.
Advertisement
