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Study Shows Role of Notch-1 Signaling Pathway in PC12 Cell Apoptosis

by Bidita Debnath on August 11, 2014 at 11:32 PM
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 Study Shows Role of Notch-1 Signaling Pathway in PC12 Cell Apoptosis

Notch-1 expression is increased in the hippocampus of Alzheimer's disease patients, suggest recent studies.

Huimin Liang and co-workers from Second Affliated Hospital of Zhengzhou University, China speculate that Notch-1 signaling may be involved in PC12 cell apoptosis induced by amyloid beta-peptide (25-35) (Aβ25-35).

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In a study reported on the Neural Regeneration Research (Vol. 9, No. 13, 2014), PC12 cells were cultured with different doses (0, 0.1, 1.0, 10 and 100 nmol/L) of N-[N-(3,5-Difuorophen-acetyl)-L-alanyl]-S-phenylglycine t-butyl ester, a Notch-1 signaling pathway inhibitor, for 30 minutes.

Then cultured cells were induced with Aβ25-35 for 48 hours. Pretreatment of PC12 cells with high doses of N-[N-(3,5-Difuorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (> 10 nmol/L) prolonged the survival of PC12 cells after Aβ25-35 induction, decreased the expression of apoptosis-related proteins caspase-3, -8, -9, increased the activity of oxidative stress-related superoxide dismutase and catalase, inhibited the production of active oxygen, and reduced nuclear factor kappa B expression.

This study indicates that the Notch-1 signaling pathway plays a pivotal role in Aβ25-35-induced PC12 apoptosis.

Source: Eurekalert
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