About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Study Shows How Melanoma can Become Drug Resistant

by Sheela Philomena on October 20, 2013 at 6:16 PM
Font : A-A+

 Study Shows How Melanoma can Become Drug Resistant

A process involving the phenotypes of tumour cells could change the appearance of melanoma tumours, say researchers. Identifying the phenotype patients exhibit may help determine which patients are more likely to benefit from existing medications while also providing an opportunity to create new targeted therapies.

Senior corresponding author Ashani Weeraratna, Ph.D., assistant professor in the Tumor Microenvironment and Metastasis Program of Wistar's NCI-designated Cancer Center, and her team focus on Wnt5A, a Wnt signaling molecule that has been found in increased levels in metastatic melanomas.

Advertisement

In order for Wnt5A to promote the phenotype switch from early in the tumor's formation to the time it becomes metastatic, the tyrosine kinase receptor ROR2 is required. When ROR2 is not present, Wnt5A is unable to promote tumor metastasis.

The only other member of the family that has been identified is ROR1, and this research was done to determine what role ROR1 might play in the progression of melanoma.
Advertisement

The researchers were able to determine that ROR1 inhibited the invasion of melanoma cells, and this receptor was targeted for degradation by Wnt5A and ROR2.

When ROR1 was silenced, the researchers observed that there was an increased rate of invasion of melanoma cells both in vitro and in vivo. The researchers also found that hypoxia - areas of low oxygen supply in the tumor - is able to induce a switch from ROR1 to ROR2 and results in an increase in levels of Wnt5A, suggesting the switch from a non-invasive ROR1-positive phenotype to an invasive ROR2-positive phenotype occurs when the tumor is exposed to hypoxic conditions.

The researchers also found that a protein HIF1a is required to increase the Wnt5A expressed. When HIF1a was removed, ROR2 was decreased, indicating that the upregulation of ROR2 via HIF1a requires Wnt5A.

The findings have been published online in the journal Cancer Discovery.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Skin Cancer Ultra-Violet Radiation Signature Drug Toxicity Melanoma 

Recommended Reading
Melanoma
Melanoma is a dangerous form of skin cancer caused largely due to exposure to the sun's damaging UV ...
Quiz on Skin Cancer
The skin is the largest organ of the body, comprising of two main layers - the epidermis and the .....
Study Finds Ipilimumab can Help Melanoma Patients Survive Up to 10 Years
A new study reveals that using monoclonal antibody ipilimumab in treating patients with advanced ......
Researchers Decode Mechanics of Resistance in Melanoma Cells
Over time, metastatic cancer cells in melanoma inevitably develop resistance to drugs despite the .....
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Skin Cancer
Skin cancer is an abnormal growth of skin cells. It can develop due to a continuous exposure to sun ...
Ultra-Violet Radiation
Ultraviolet radiations are electromagnetic radiations with wavelengths shorter than the shortest wav...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use