Use of antihypertensive drugs is high among pregnant women, yet safety remains unclear, finds research published in Hypertension.
Use of high blood pressure drugs during pregnancy is becoming increasingly common, said Brian T. Bateman, M.D., lead author and Assistant Professor of anesthesia at Harvard Medical School in Boston, Mass."While we know high blood pressure, or hypertension, occurs in about 6 percent to 8 percent of all pregnancies, we know little about how women and their doctors treat the condition," he said.Researchers studied a database of more than 1 million Medicaid patients, of whom 48,453 (4.4 percent) filled prescriptions for high blood pressure drugs during their pregnancies. They found:
1. Antihypertensive drug use increased from 3.5 percent to 4.9 percent between 2000 and 2006.
2. Antihypertensive drug users were older than non-users, more likely to have diabetes or kidney disease, and more likely to be Caucasian or African-American than Hispanic or Asian. 3. Nearly 2 percent of pregnant women filled prescriptions for these drugs during the first trimester; 1.7 percent during the second trimester; and 3.2 percent during the third trimester. 4. The drugs prescribed included ACE inhibitors and angiotensin receptor blockers both of which have been shown in studies to have harmful side effects during pregnancy. Limited information is available about which antihypertensive drugs are safest and most effective for treating high blood pressure during pregnancy, Bateman said.