A joint study conducted by researchers at The Ohio State University Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute has shed light on how exactly the Human papillomavirus (HPV) harms our body.
HPV has been found to increase risk of cervical, head and neck and anal cancers among others but until now, scientists had not been able to find out how exactly the virus affects the cells. Now researchers have found that when the virus inserts its DNA into the human DNA, it damages the chromosomes and genes around the area of insertion.
Cervical Cancer - Incidence
Cervical cancer is the second most common cancer among women and is the primary cause of cancer-related deaths in developing countries
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Researchers led by Dr David Symer examined 10 cancer-cell lines and two head and neck tumor samples from patients and made use of whole-genome sequencing and several molecular assays, including RNA sequencing, spectral karyotyping (SKY) and fluorescence in situ hybridization (FISH). The study has been published in the journal Genome Research.
"HPV can act like a tornado hitting the genome, disrupting and rearranging nearby host-cell genes. This can lead to overexpression of cancer-causing genes in some cases, or it can disrupt protective tumor-suppressor genes in others. Both kinds of damage likely promote the development of cancer", Symer said.
Source: Medindia
Source: Medindia
Genetic Testing of Diseases
Genetic testing helps to confirm a genetic condition in an individual and involves q complex laboratory techniques
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 EpigeneticsIn the recent years 'epigenetics' represents inheritable changes in gene expression that do not include DNA alterations. | Advertisement
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Pap smear and Cervical Cancer Screening
Pap smear is the most common test used in screening cervical cancer caused by an infection with human papilloma virus. Pap smear should be repeated every 1 to 3 years till the age of 65 years.
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