About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Study Says Exposure to Micronutrients Pre-pregnancy Associated With Gene Modifications in Offspring

by Sheela Philomena on February 23, 2012 at 12:10 PM
Font : A-A+

 Study Says Exposure to Micronutrients Pre-pregnancy Associated With Gene Modifications in Offspring

Babies of women who were given micronutrient supplements before they become pregnant had gene modifications at birth, reveals study.

The changes to the genes, called methylation, have previously been associated with the development of the immune system, although this study did not provide direct evidence that the activity of these genes has changed. The research, funded by the BBSRC, was published today in the journal Human Molecular Genetics in advance online publication (DOI number DDS026).

Advertisement

Professor Nabeel Affara, lead author of the study from the University of Cambridge, said: "The mechanism by which micronutrients influence methylation changes is still to be worked out, but it is known from other work that the genes of the immune system undergo such changes as immune function develops, particularly in early postnatal stages and early childhood.

"These changes are part of the normal development of the immune system provided adequate nutrition is available. Where this is not the case, different patterns of methylation may occur, altering the activity of key genes and therefore potentially the effectiveness of the immune system. The result is likely to be reduced ability to fight infection and hence susceptibility to infectious diseases."
Advertisement

The study used DNA samples from a Medical Research Council (MRC) micronutrient supplementation trial where women attempting to get pregnant are given either a cocktail of micronutrients or a placebo until pregnancy is confirmed (approximately an 8 weeks period). The research was conducted in The Gambia where there is seasonal variation in the availability of micronutrients with an alternation between the dry season (when they harvest and food is plentiful) and the wet season (when there is less food available and therefore poorer nutrition). Individuals born in the wet, nutritionally poor season have been found to be more susceptible to infection.

Professor Affara added: "This has huge public health implications for regions of the world where food security is an issue. If we have an improved understanding of what nutrition is important and the mechanisms by which this important environmental factor interacts with gene function, we can target nutritional intervention to improve health in later life."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World AIDS Day 2022 - Equalize!
Test Your Knowledge on Sugar Intake and Oral Health
Test  Your Knowledge on Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
DNA Finger Printing Carbohydrates and Its Role in Obesity Undetected Nutrient Deficiencies: the Cause of Ill Health Right Types of Carbohydrates Dark Green Leafy Greens Packed With Essential Nutrients 

Most Popular on Medindia

Loram (2 mg) (Lorazepam) The Essence of Yoga Accident and Trauma Care Indian Medical Journals Sinopril (2mg) (Lacidipine) Nutam (400mg) (Piracetam) Sanatogen Vent Forte (Theophylline) Selfie Addiction Calculator Post-Nasal Drip
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Study Says Exposure to Micronutrients Pre-pregnancy Associated With Gene Modifications in Offspring Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests