A new study has revealed that a protein called PUMA (p53 upregulated modulator of apoptosis) contributes to ulcerative colitis.
Ulcerative colitis (UC) is an inflammatory bowel disease thought to be related to aberrant activation of the immune system in the intestine. Recent research has also suggested that regulated cell death (apoptosis) of the intestinal epithelial cells is a contributing factor to the pathogenesis.
However, the molecular mechanisms that control the cellular response to inflammation are incompletely understood.
PUMA levels were also increased in the diseased tissues of UC patients.
The researchers are hopeful that PUMA could represent a promising target for the development of new UC therapies.
The study is published in the Journal of Clinical Investigation.