About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Study Reveals Mechanism Behind the Bird Flu Transmission from Person-to-person

by Medindia Content Team on October 5, 2007 at 6:29 PM
Font : A-A+

Study Reveals Mechanism Behind the Bird Flu Transmission from Person-to-person

A team of researchers from the University of Wisconsin-Madison has identified a key step that the H5N1 avian flu virus must take to facilitate its easy transmission from one person to another.

Lead researcher Yoshihiro Kawaoka, a virologist at the UW-Madison School of Veterinary Medicine, has revealed that a single change a viral surface protein enables the H5N1 virus to settle into the upper respiratory system, which "may provide a platform for the adaptation of avian H5N1 viruses to humans and for efficient person-to-person virus transmission."

Advertisement

"The viruses that are in circulation now are much more mammalian-like than the ones circulating in 1997. The viruses that are circulating in Africa and Europe are the ones closest to becoming a human virus," says Kawaoka, an internationally recognized authority on influenza.

He said that though other currently undetermined changes are required for the virus to become a human pathogen of pandemic proportions, establishing itself in the upper respiratory system is necessary as that enables easy transmission of the virus through coughing and sneezing.
Advertisement

The researchers involved two different avian viruses isolated from a single patient—one from the lungs and the other from the upper respiratory system—in the study.

They found that the virus from the upper respiratory system exhibited a single amino acid change in one of the key proteins for amplification of influenza virus genes.

Kawaoka says that such a change promotes better virus replication at lower temperatures, such as those found in the upper respiratory system, and in a wider range of cell types.

"This change is needed, but not sufficient. There are other viral factors needed to cause a viral pandemic" strain of bird flu, he said.

The researchers, however, are convinced that it is only a matter of time, as more humans and other animals are exposed to the virus, before H5N1 virus takes those steps and evolves into a virus capable of causing a pandemic.

The study has been published in the journal Public Library of Science Pathogens.

Source: ANI
VEN/C
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Bird Flu Flu Swine Flu 

Recommended Reading
Bird Flu
Bird flu (avian influenza/avian flu) is a disease caused by an influenza virus (H5N1) that ......
Bird Flu can Spread from Mother to Fetus: Study
The deadly H5N1 strain of bird flu can pass through the placenta of a pregnant woman to her unborn ....
Humans Could Face Greater Bird Flu Risk, Indonesia Warns
Researchers in Indonesia, the country worst hit by bird flu, have found preliminary evidence which ....
Swine Flu
Swine flu, a type of influenza caused by a new strain of the H1N1 Type A influenza virus has origina...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use