About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Study Reveals Link Between LDL and Vascular Disease

by Medindia Content Team on October 26, 2007 at 4:06 PM
Font : A-A+

Study Reveals Link Between LDL and Vascular Disease

According to a report published online this week in EMBO, low-density lipoprotein (LDL), a transporter of cholesterol, may also contribute to vascular diseases by a previously unidentified mechanism. The study reveals a link between native LDL (nLDL) and the vascular endothelial growth factor receptor 1 (VEGFR1), which plays a central role in blood vessel formation.

LDL is responsible for transporting cholesterol from the liver to peripheral tissues. During transit in the blood, cholesterol can be deposited causing the formation of plaques that lead to hardening of the arteries. Vascular diseases such as thrombosis, stroke and heart attacks are associated with this condition, and are attributed to eleven deaths every hour in the UK alone.

Advertisement

Using cell lines and mouse models, Yoshiro Maru and colleagues found that when nLDL is bound to the LDL receptor, it can activate VEGFR1 and accelerate migration of macrophages, scavenger cells that accumulate in the plaques. Both effects could contribute to the progression of the plaques and blocking of the arteries. The authors hope that their discovery of the link between VEFGR1 and nLDL could be exploited as a potential therapeutic target for medical applications.

Source: Eurekalert
GAN/V
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
Long-Term Glycemic Control - A Better Measure of COVID-19 Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
High Cholesterol Diet Lifestyle and Heart Disease Natural Remedies for Cholesterol – How Effective Are They? Lipid Profile Screening Coconut Oil Top Foods to Lower Triglycerides Importance of Fat in the Diet Dyslipidemia Lipid Profile 

Recommended Reading
High Density Lipoproteins
HDL is a type of Lipoprotein. Lipoproteins, as the name suggests, are a class of biochemical ......
Study Finds Association Between Low Cholesterol Levels and Cancer
Millions of Americans take statins to lower their cholesterol, but how low should you go? Many ......
Coconut Oil
Coconut oil is a healthy addition to the diet. The oil has good fatty acids and is readily burned in...
Dyslipidemia
Dyslipidemia is a condition due to imbalance of fats in blood. Find out more about dyslipidemia, its...
High Cholesterol
High cholesterol level in blood are a risk for heart disease and stroke. They get deposited in the w...
Importance of Fat in the Diet
Fat along with protein and carbohydrate are essential nutrients for normal body function and for mai...
Lipid Profile
Lipid profile or lipid panel is a collection of blood tests that help to calculate the levels of cho...
Lipid Profile Screening
Lipid profile test/screening is done by measuring total cholesterol, HDL-cholesterol and LDL – chole...
Natural Remedies for Cholesterol – How Effective Are They?
Certain natural remedies are effective in controlling high cholesterol, when aided by lifestyle chan...
Top Foods to Lower Triglycerides
High triglyceride levels may lead to heart disease. Keep your triglyceride levels in check with thes...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use