About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Study Reveals How Obesity Leads to Diabetes

by Rajashri on July 10, 2009 at 11:56 PM
Font : A-A+

 Study Reveals How Obesity Leads to Diabetes

In a finding that could lead to the design of a drug to prevent the disease, Monash University researchers have found how obesity leads to type 2 diabetes.

Though obesity is associated as a leading cause of diabetes, no one has understood the exact mechanism of how obesity inhibits the body's ability to use insulin leading to type 2 diabetes until now.

Advertisement

Now, the research team, led by Associate Professor Matthew Watt, discovered that fat cells release a novel protein called PEDF (pigment epithelium-derived factor), which triggers a chain of events and interactions that lead to development of Type 2 diabetes.

"When PEDF is released into the bloodstream, it causes the muscle and liver to become desensitised to insulin. The pancreas then produces more insulin to counteract these negative effects, " Watt said.
Advertisement

"This insulin release causes the pancreas to become overworked, eventually slowing or stopping insulin release from the pancreas, leading to Type 2 diabetes.

"It appears that the more fat tissue a person has the less sensitive they become to insulin. Therefore a greater amount of insulin is required to maintain the body's regulation of blood-glucose.

"Our research was able to show that increasing PEDF not only causes Type 2 diabetes like complications but that blocking PEDF reverses these effects. The body again returned to being insulin-sensitive and therefore did not need excess insulin to remain regulated," Watt added.

The findings were published today in respected journal Cell Metabolism.

Source: ANI
RAS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Organ Donation Week 2022 - 'Take the Pledge to Save Lives'
Test your Knowledge on Heart Transplantation
Test Your Knowledge on Lung Transplantation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Bariatric Surgery Obesity Diabetes Bulimia Nervosa Diabetes - Self-Monitoring of Blood Glucose (SMBG) Insulin Delivery Devices Diabetes and Exercise Body Mass Index Stress Relief Through Alternative Medicine Stress and the Gender Divide 

Most Popular on Medindia

Vent Forte (Theophylline) Loram (2 mg) (Lorazepam) Post-Nasal Drip How to Reduce School Bag Weight - Simple Tips The Essence of Yoga Hearing Loss Calculator Nutam (400mg) (Piracetam) Drug - Food Interactions Color Blindness Calculator Sanatogen
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use