About My Health Careers Internship MedBlogs Contact us

Study on Zebrafish Reveals Blood Vessel Growth in Humans

by Medindia Content Team on October 15, 2007 at 2:51 PM
Font : A-A+

Study on Zebrafish Reveals Blood Vessel Growth in Humans

Researchers have discovered a key molecular pathway that plays an important in angiogenesis, the growth of new blood vessels.

The study, led by Massimo Santoro, PhD, UCSF and Didier Stainier, PhD, UCSF professor of biochemistry and biophysics, was conducted on the zebrafish, the tiny, blue-and-silver striped denizen of India's Ganges River.


The team determined that two well known signalling molecules, birc2 and TNF, are vital to the survival of endothelial cells, which in zebrafish embryos line the blood vessels and maintain the integrity of the blood vessel wall during vascular development.

"The pathway these molecules make up during vascular development has not been looked at before, it offers a new target for therapeutic strategies," Nature Genetics quoted Stainier, as saying.

The birc2 gene belongs to a family of proteins that balances the control between cell survival and cell death (apoptosis). A cell, when it detects that it is irreparably damaged, induces apoptosis.

A dynamic balance between endothelial cell survival and apoptosis determines the integrity of the blood vessel wall.

The study included the examination of the zebrafish with unusual physical attributes in order to identify the mutated genes that were responsible for the traits.

"We began with a genetic mutant that displayed vascular haemorrhage associated with vascular defects, and soon proved that the mutant had a defective birc2 gene," Santoro said.

"Without the birc2 gene, haemorrhage and blood pooling occurred, resulting in vascular regression and cell death," he added.

From the study the researchers come to the conclusion that the findings offers an important insight into the development of the vascular system during embryonic development.

And also suggests a potential target for inhibiting the blood vessels that fuel cancers, diabetic eye complications and atherosclerosis.

"The zebrafish has proven to be an important model for discovering molecules relevant to human disease. We expect this finding will offer important insights into blood vessel formation in humans," Santoro said.

The team discovered the critical role of birc2 and TNF in blood vessel health in the zebrafish embryo, through a series of genomic analyses and biochemical studies.

It was revealed that birc2 was needed for the formation of the tumour necrosis factor receptor complex 1, a group of proteins and peptides, which by initiating signals activate cell survival.

Tumour necrosis factor promotes NF-kB activation. NF-kB is a protein complex transcription factor involved in the transfer of genetic information.

In further tests, it was proved that there was an existence of a genetic link between the birc2/NF-kB pathway, which was critical for vascular health and endothelial cell survival.

"Studies on vascular development are important so that we can better understand the molecular basis of how endothelial cell-related pathologies such as cancer, diabetic eye complications, known as retinopathies, atherosclerosis and system lupus develop," Santoro said.

"It can also help us design new therapeutic strategies for these diseases," he said.

The study is published in Nature Genetics.

Source: ANI

News A-Z
News Category
What's New on Medindia
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
Long-Term Glycemic Control - A Better Measure of COVID-19 Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Thalassemia Vasculitis Blood in Stools - Symptom Evaluation Bombay Blood Group 

Recommended Reading
Inflammatory Protein Creates Pathway to Angiogenesis and Breast Cancer
A research at The University of Texas M. D. Anderson Cancer Center shows that a familiar ......
Blood in Stools - Symptom Evaluation
Blood in stools results from bleeding that arises from any part of the digestive tract. Causes of bl...
Bombay Blood Group
Bombay blood group is a rare blood type in which the people have an H antigen deficiency. They can r...
Thalassemia is an inherited blood disorder passed on through parental genes causing the body to prod...
Vasculitis is an inflammation of the blood vessels of the body that can affect people of all ages; i...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use