About My Health Careers Internship MedBlogs Contact us

Study Insists Not to Use Experimental HPV Vaccine Drug to Treat Infection

by Medindia Content Team on August 17, 2007 at 1:19 PM
Font : A-A+

Study Insists Not to Use Experimental HPV Vaccine Drug to Treat Infection

GlaxoSmithKline's experimental human papillomavirus vaccine Cervarix does not accelerate the clearance of HPV among women infected with the virus and should not be used to treat infection, according to a National Cancer Institute-funded study published Wednesday in the Journal of the American Medical Association, the Wall Street Journal reports.

Cervarix has been shown to be 100% effective in preventing infection with HPV strains 16 and 18, which together cause about 70% of cervical cancer cases. Researchers in a 2006 study published in the online edition of the Lancet also found that Cervarix prevented infection with HPV strains 31 and 45, which together with strains 16 and 18, cause more than 80% of cervical cancer cases.


The Australian Therapeutic Goods Administration in June approved the vaccine for girls and women ages 10 to 45, and the European Committee for Human Medicinal Products last month recommended the vaccine for sale and marketing in the European Union. FDA has granted a standard 10-month review of the vaccine and most likely will take action on GSK's application in January 2008, according to analysts at Evolution Securities.

Study, Reaction

For the study, Allan Hildesheim, a senior investigator at NCI, and colleagues between June 2004 and December 2005 enrolled 2,189 women ages 18 to 25 in Costa Rica who tested positive for HPV DNA at the time of enrollment. About half of the women in the study were given Cervarix and half were given the hepatitis A vaccine.

According to the findings, 33.4% of the women who received Cervarix had cleared HPV infection after six months, compared with 31.6% in the control group (Hildesheim et al., JAMA, 8/15). After one year, 48.8% of women who received Cervarix had cleared the infection, compared with about 49.8% who had not received the vaccine. The study also found that most HPV infections, regardless of the strain, clear spontaneously over a period of six months to two years.

"You should not get [Cervarix] because you want to treat an existing infection," Hildesheim said. He added, "The question that has not yet been answered is whether protecting [a woman] from reinfection of a virus that she has previously been infected with, and successfully cleared, will in fact reduce that woman's risk of getting cervical precancer and cancer".

GSK spokesperson Liad Diamond, said the results of the study are "completely expected." GSK and Merck, which makes the HPV vaccine Gardasil, said their vaccines are not intended to treat existing infections, adding that the study's findings confirm their companies' research.

Source: Kaiser Family Foundation

News A-Z
News Category
What's New on Medindia
Guide to Brushing Your Teeth the Right Way
Resting Heart Rate
Is COVID-19 Vaccination during Pregnancy Safe?
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Cervical Cancer Signature Drug Toxicity Flu Uterine Cancer Anal Warts Top 10 Vaccine Myths Debunked Human Papillomavirus Infection 

Recommended Reading
Cervical Cancer - Incidence
Cervical cancer is the second most common cancer among women and is the primary cause of ......
HPV Vaccine Won't Fight Existing Infections
A new study has found that the human papillomavirus (HPV) vaccine is not effective in preventing ......
FDA Grants Standard Review for GSK's Experimental HPV Vaccine Cervarix
GlaxoSmithKline on Thursday announced that FDA has granted a standard 10-month review of its ......
Anal Warts
Anal warts or genital warts are soft bumps caused by Human Papilloma Virus and are a sexually transm...
Cervical Cancer
Cancer cervix refers to cancerous growth in the cervix and usually occurs in the transition called ...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Human Papillomavirus Infection
Human papillomavirus (HPV) infection, depending on the human papillomavirus that causes it, can resu...
Top 10 Vaccine Myths Debunked
Childhood vaccination has saved many lives, yet lots more has to be done to increase awareness and e...
Uterine Cancer
Uterine Cancer or Cancer of the Uterus (or Endometrial Cancer) refer to cancers affecting the uterus...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use