Medindia LOGIN REGISTER
Medindia
Advertisement

Study Gives New Insight into H5N1ís High Fatality Rate

by VR Sreeraman on September 28, 2007 at 4:18 PM
Study Gives New Insight into H5N1ís High Fatality Rate

Avian influenza H5N1 virus not only affects the respiratory system but gastrointestinal tract, immune and central nervous systems also, and it can be transmitted from mother to foetus through placenta, say researchers.

The findings published in the journal Lancet are based on a collaborative study by researchers from Beijing University, Columbia University Mailman School of Public Health and SUNY Downstate, which sheds light on the anatomic distribution of the virus and its pathogenesis.

Advertisement

Initially, the virus seemed to be limited to the lungs, but later reports have suggested that influenza A H5N1 could spread beyond the lungs. Lung damage is severe and disproportionate to the number of cells that are infected, with macrophages and T-cells targeted for infection.

The new study suggests that lung damage is not due to virus replication alone, and supports the theory that indirect effects, such as soluble factors known as cytokine and chemokines, are important, say the researchers.
Advertisement

According to them, the newly obtained data are important in the clinical, pathological, and epidemiological investigations of human H5N1 infection.

The researchers say that the findings also have widespread implications for public health and healthcare providers, because though there has been considerable progress in developing surveillance networks, diagnostic tests, drugs and vaccines, scientists have to date achieved limited information about the mechanisms by which H5N1 causes disease.

"The work helps us to understand H5N1's high fatality rate, as well as serving as model for global collaboration in the field of emerging infectious diseases," said the study's senior author Dr. W. Ian Lipkin, director of the Centre for Infection and Immunity at Columbia University Mailman School of Public Health and professor of Epidemiology, Neurology, and Pathology at Columbia.

Source: ANI
LIN/C
Font : A-A+

Advertisement

Advertisement
Advertisement

Latest Bird Flu News

Japan Records Second Avian Flu Outbreak of the Season
Japan's Ministry of Agriculture confirmed a new highly pathogenic avian flu case at an Ibaraki poultry farm, marking the country's second outbreak this season.
Gene-Edited Chickens Hold the Key to Combat Bird Flu
Scientists have successfully utilized gene editing techniques to control the transmission of avian influenza among chickens.
Mutational Changes in Bird Flu Virus Signal Potential Pandemic
The study reports documented cases of A (H3N8) avian influenza viruses crossing species boundaries and affecting a range of mammals, including dogs and horses.
Genetic Change Boosts Bird Flu Severity
Researchers monitored the continuing avian flu pandemic to gauge its evolving risk to both humans and birds.
Bird Flu in Brazil: 6-month Health Emergency Declared
Bird flu in Brazil: Authorities are watching if the bird flu virus H5N1 is mutating into a form which can spread amongst humans.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Study Gives New Insight into H5N1ís High Fatality Rate Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests